公开(公告)号：US20150004594A1

公开(公告)日：2015-01-01

申请号：US14121488

申请日：2014-09-11

Applicant: STC.UNM

Inventor： Scott S. Sibbett

IPC: G01N33/543

CPC classification number: G01N33/54386 ,  G01N33/558 ,  G01N33/56988 ,  G01N2333/005

Abstract: The present invention provides a semi-quantitative lateral flow assay device and method for generating semi-quantitative data from a lateral flow assay. The device comprises a thin, porous hydrophilic substrate wherein the substrate includes a star-shaped or other geometry taken in plan view having a liquid sample-receiving central region and multiple arms that extend or radiate out from the central region. Each arm includes a reaction zone formed by the presence of an analyte-capturing agent wherein the reaction zone of each arm is located at a different distance from the central region such that the analyte in the sample is captured accumulates in different quantities at at least some of the reaction zones of the arms in a manner that can be analyzed to yield semi-quantitative data from lateral flow assays. The reaction zones on the arms can be analyzed visually and/or by software analysis of a digital image based on color saturation, grayscale, or other characteristics of the reactions zones due to the presence of different amounts of analyte to produce semi-quantitative data of the total loading of a virus or other agent of interest of a patient's blood.

Abstract translation: 本发明提供了一种半定量侧流测定装置和用于从侧流测定产生半定量数据的方法。 该装置包括薄的多孔亲水基底，其中基底包括在平面图中取得的星形或其他几何形状，具有液体样品接收中心区域和从中心区域延伸或辐射出的多个臂。 每个臂包括通过存在分析物 - 捕获剂形成的反应区，其中每个臂的反应区位于与中心区不同的距离处，使得捕获的样品中的分析物在至少一些 的臂的反应区域以可以分析的方式产生来自侧向流动测定的半定量数据。 可以通过视觉和/或通过基于颜色饱和度，灰度或反应区域的其他特征的数字图像的软件分析来分析臂上的反应区域，这是由于存在不同量的分析物以产生半定量数据 患者血液感兴趣的病毒或其他药剂的总负荷。

公开(公告)号：US20170234673A1

公开(公告)日：2017-08-17

申请号：US15583350

申请日：2017-05-01

Applicant: STC.UNM

Inventor： Scott S. Sibbett

IPC: G01B7/16 ,  G01L9/00

CPC classification number: G06F3/0414 ,  G01L1/205

Abstract: A pliable pressure sensitive sensor device and method of making the same is provided. The sensor includes first and second pliable protective layers, which cover sets of conductive fibers that spatially separated by an electrically conductive pliable layer, which deforms in response to a pressure event. The fiber sets form a grid pattern and are in electrical communication with sets of electrical contacts located in predetermined locations along the fibers. In response to a pressure event in proximity to the contact, the pliable layer deforms and increases the amount of surface area in contact with an electrical contact whereby an electrical resistance at an individual electrical contact decreases in response to the pressure event.