公开(公告)号：US20180110774A1

公开(公告)日：2018-04-26

申请号：US15570042

申请日：2016-04-28

Applicant: STC.UNM

Inventor： Laura V. Gonzalez Bosc ,  Levi D. Maston ,  Thomas Resta

IPC: A61K31/495 ,  A61P9/12 ,  A61K45/06 ,  A61K9/00

CPC classification number: A61K31/495 ,  A61K9/0078 ,  A61K31/192 ,  A61K31/343 ,  A61K31/426 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5578 ,  A61K45/06 ,  A61P9/12 ,  C07D277/38 ,  C07D295/108 ,  A61K2300/00

Abstract: Methods and composition for treating or preventing pulmonary hypertension are provided. In certain aspects, compounds that inhibit TH17 cell maturation or activity, such as retinoic acid receptor-related orphan nuclear receptor (ROR) inhibitors, are used to for the treatment of pulmonary hypertension.