公开(公告)号：US10550165B2

公开(公告)日：2020-02-04

申请号：US15691017

申请日：2017-08-30

Applicant: STEMRIM INC. ,  OSAKA UNIVERSITY

Inventor： Katsuto Tamai ,  Takehiko Yamazaki ,  Tsutomu Kanezaki ,  Shigeru Sakurai ,  Yukiko Noguchi ,  Mayumi Endo ,  Natsumi Hamabuchi ,  Kana Naito

IPC: A61K38/00 ,  C07K14/00 ,  C07K14/47 ,  A61K38/17

Abstract: (Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFRα-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body.(Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFRα-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFRα-positive cells.