公开(公告)号：US20030073592A1

公开(公告)日：2003-04-17

申请号：US10098767

申请日：2002-03-14

Applicant: STERIS INC.

Inventor： Gerald E. McDonnell ,  Herbert J. Kaiser ,  Kathleen M. Antloga ,  Jennifer A. Scocos

IPC: C02F005/08 ,  C11D001/00

CPC classification number: A61L2/186 ,  A61K31/327 ,  A61L2/0082 ,  A61L2/0088 ,  A61L2/14 ,  A61L2/208 ,  A61L2/22 ,  A61L2202/24 ,  C11D3/3947 ,  C11D11/0023

Abstract: A surface which carries a material which is infected with prions is cleaned with an alkaline cleaning solution to remove as much proteinaceous material as possible from the surface. The cleaning agent is an alkaline cleaning agent which attacks prions remaining on the surface and which attacks prions removed from the surface during the cleaning step. After the cleaning solution is drained, a solution of surfactants, buffers, and heavy metal free corrosion inhibitors is circulated over the surface at 50null-60null C. The surfactants disperse and unclump the prion-contaminated material. A strong oxidant, preferably peracetic acid, is added to the solution to bring the peracetic acid concentration to 1,000-2,500 ppm. The peracetic acid or other strong oxidant attacks the prions, particularly the unclumped prion strands, deactivating the prions. After rinsing and drying, the surface may be wrapped in a microbe impermeable barrier and subjected to terminal sterilization, such as steam autoclaving.

Abstract translation: 携带被朊病毒感染的材料的表面用碱性清洁溶液清洗，以从表面去除尽可能多的蛋白质材料。 清洁剂是一种碱性清洁剂，其在清洁步骤中侵袭残留在表面上的朊病毒，并且其在表面上去除朊病毒。 清洁溶液排干后，表面活性剂，缓冲剂和无重金属的缓蚀剂溶液在50°-60°C的表面循环。表面活性剂分散并释放朊病毒污染物质。 向该溶液中加入强氧化剂，优选过乙酸，使过乙酸浓度达到1,000-2,500ppm。 过乙酸或其他强氧化剂会侵袭朊病毒，特别是未切开的朊病毒链，使朊病毒失活。 在漂洗和干燥之后，表面可以包裹在微生物不渗透屏障中并进行终端灭菌，例如蒸汽高压灭菌。

公开(公告)号：US20030086820A1

公开(公告)日：2003-05-08

申请号：US10116090

申请日：2002-04-03

Applicant: STERIS INC.

Inventor： Gerald E. McDonnell ,  Kathleen M. Antloga ,  Herbert J. Kaiser

IPC: A61L002/00

CPC classification number: A61L2/186 ,  A61K31/327 ,  A61L2/0082 ,  A61L2/0088 ,  A61L2/14 ,  A61L2/208 ,  A61L2202/122 ,  A61L2202/24 ,  C11D3/3947 ,  C11D11/0023

Abstract: A surface which carries a material which is infected with prions is cleaned with an alkaline cleaning solution to remove as much proteinaceous material as possible from the surface. The solution contains an alkaline cleaning agent which attacks prions remaining on the surface and which attacks prions removed from the surface during the cleaning step. After the cleaning step, the surface is exposed to a strong gaseous oxidant, preferably hydrogen peroxide vapor. The hydrogen peroxide or other strong oxidant attacks the prions, particularly the unclumped prion strands, deactivating the prions.

Abstract translation: 携带被朊病毒感染的材料的表面用碱性清洁溶液清洗，以从表面去除尽可能多的蛋白质材料。 该溶液含有一种碱性清洁剂，其在清洁步骤中侵蚀残留在表面上的朊病毒，并且会从表面去除朊病毒。 在清洁步骤之后，表面暴露于强气体氧化剂，优选过氧化氢蒸气。 过氧化氢或其他强氧化剂会攻击朊病毒，特别是未切开的朊病毒链，使朊病毒失活。

公开(公告)号：US20040263177A1

公开(公告)日：2004-12-30

申请号：US10896609

申请日：2004-07-21

Applicant: STERIS Inc.

Inventor： Herbert J. Kaiser ,  Michael A. Centanni

IPC: G01N027/60 ,  B32B009/00

CPC classification number: G01N27/221

Abstract: A method and apparatus for monitoring the concentration of metal cations in a chemical solution. In a preferred embodiment, the chemical solution is a solution for derouging or passivating stainless steel. A capacitive sensor provides data indicative of the concentration of chemical components (e.g., iron or chromium) in the chemical solution.

Abstract translation: 一种用于监测化学溶液中金属阳离子浓度的方法和装置。 在优选的实施方案中，化学溶液是用于开槽或钝化不锈钢的溶液。 电容传感器提供指示化学溶液中化学成分（例如铁或铬）浓度的数据。

公开(公告)号：US20040120850A1

公开(公告)日：2004-06-24

申请号：US10326484

申请日：2002-12-20

Applicant: STERIS Inc.

Inventor： Herbert J. Kaiser

IPC: A61L002/00 ,  B01J019/08

CPC classification number: A61L2/202 ,  A61L2/10 ,  A61L2/24 ,  C01B13/10

Abstract: A treatment system for treating objects (e.g., medical instruments) with ozone gas. The ozone treatment system includes a treatment tank wherein the objects are exposed to ozone. In a preferred embodiment, the ozone is generated within the treatment tank by exposing an oxygen-containing gas to ultraviolet radiation produced by a laser.

Abstract translation: 一种用臭氧气体处理物体（例如医疗器械）的处理系统。 臭氧处理系统包括处理槽，其中物体暴露于臭氧。 在优选实施例中，通过将含氧气体暴露于由激光产生的紫外线辐射而在处理槽内产生臭氧。