公开(公告)号：US20130330836A1

公开(公告)日：2013-12-12

申请号：US13902468

申请日：2013-05-24

Applicant: STMicroelectronics S.r.I.

Inventor： Lucio Renna ,  Clelia Carmen Galati ,  Natalia Maria Rita Spinella ,  Piero Giorgio Fallica

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/6454 ,  G01N33/551

Abstract: A diagnostic device includes a photodiode (2) formed by a body (10) of semiconductor material having a first surface (6a), an integrated optical structure (30) on the first surface and having a second surface (34a), and at least one detection region (50) on the second surface. The at least one detection region includes at least one receptor (52) that binds to a corresponding target molecule (MB) that can be mated with a corresponding marker (54), which, when excited by radiation having a first wavelength (λe), emits radiation having a second wavelength (λf) that can be detected by the photodiode. The integrated optical structure includes at least a first layer (34, 62) of a first material having a first refractive index (n1). The first layer has a thickness substantially equal to an integer and odd multiple of one fourth of the first wavelength (λe) divided by the first refractive index.

Abstract translation: 诊断装置包括由半导体材料的本体（10）形成的光电二极管，所述半导体材料具有第一表面（6a），在第一表面上具有集成光学结构（30），并具有第二表面（34a），并且至少 在第二表面上的一个检测区域（50）。 所述至少一个检测区域包括至少一个与相应的靶分子（MB）结合的受体（52），所述靶分子（MB）可以与相应的标记物（54）相配合，所述对应标记物当被具有第一波长的辐射激发时， 发射具有可由光电二极管检测的第二波长（羔羊）的辐射。 集成光学结构至少包括具有第一折射率（n1）的第一材料的第一层（34,62）。 第一层具有基本上等于第一波长（lambdae）四分之一的整数和奇数倍除以第一折射率的厚度。