公开(公告)号：US20230076197A1

公开(公告)日：2023-03-09

申请号：US17962560

申请日：2022-10-10

Applicant: SUN YAT-SEN UNIVERSITY

Inventor： Weiwei SU ,  Yonggang WANG ,  Peibo LI ,  Hongyu RAO ,  Hao WU

IPC: A61K36/185 ,  A61P31/14

Abstract: An application of HJT aqueous extract in the preparation of drugs against a Blue-ear disease is provided. For the first time, it is found in the present invention that HJT extract has a significant effect of preventing and treating the Blue-ear disease. Specifically, through experiments of qRT-PCR and immunofluorescence techniques, the present invention has proved that HJT extract can significantly inhibit infection and replication of PPRSV with significant antiviral effect, so that it is expected to become a new type of biologically active substance for prevention and treatment of Blue-ear disease. The product prepared by the method can be used as natural antiviral drugs for the prevention and treatment of the Blue-ear disease, realizes the comprehensive utilization of HJT plants, and improves its value, which has a good application prospect.

公开(公告)号：US20220362186A1

公开(公告)日：2022-11-17

申请号：US17274779

申请日：2020-02-01

Applicant: SUN YAT-SEN UNIVERSITY

Inventor： Hao WU ,  Taobin CHEN ,  Yonggang WANG ,  Weiwei SU

IPC: A61K31/192 ,  A61P31/04

Abstract: The present invention relates to new medicine application of p-hydroxyphenylpropionic acid. Experiments prove that p-hydroxyphenylpropionic acid has a remarkable pharmacological effect in inhibiting respiratory tract infection, particularly inhibiting pulmonary edema, inflammatory cell infiltration and cell apoptosis in lung injury and delaying lung function degradation of mice. Therefore, the present invention discloses the application of p-hydroxyphenylpropionic acid to prepare a medicine for preventing and treating respiratory tract infection, particularly pneumonia, pulmonary edema or pulmonary epithelial and/or endothelial cell necrosis in lung injury for the first time.