公开(公告)号：US20210236493A1

公开(公告)日：2021-08-05

申请号：US17266961

申请日：2019-08-27

Applicant: SUNSHINE LAKE PHARMA CO., LTD.

Inventor： Jianzhou HUANG ,  Qingyun REN ,  Jinfeng XIONG ,  Yang LIU ,  Xinchang LIU ,  Siegfried GOLDMANN ,  Yingjun ZHANG ,  Yifeng WANG ,  Weishun LIU ,  Fangcai YU

IPC: A61K31/5025 ,  A61K31/7068 ,  A61K31/675 ,  A61K38/21 ,  A61K38/20 ,  A61K31/7056 ,  A61K31/52 ,  A61K31/427 ,  A61K31/7072 ,  A61K31/429 ,  A61P31/20 ,  C07D471/04

Abstract: A fused tricyclic compound and application thereof in medicine, especially as a medicament for the treatment and/or prevention of hepatitis B. Specifically, the present invention relates to a compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein each variable is as defined in the specification. The present invention also relates to the use of a compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof as a medicament, especially as a medicament for the treatment and/or prevention of hepatitis B.