专利检索 ap:("SUZHOU INSTITUTE OF SYSTEMS MEDICINE") AND inv:"Hongcheng CHENG" 第 1 页

1.

发明公开
T CELL RECEPTOR, AND PREPARATION METHOD AND USE THEREOF 审中-公开

公开(公告)号：US20240358832A1

公开(公告)日：2024-10-31

申请号：US18763813

申请日：2024-07-03

申请人： SUZHOU INSTITUTE OF SYSTEMS MEDICINE

发明人： Guideng LI , Hongcheng CHENG , Yajing QIU , Yue XU

IPC分类号： A61K39/00 , A61P35/00 , C07K14/725 , C12N5/0783 , C12N15/10 , C12N15/86

CPC分类号： A61K39/4632 , A61K39/4611 , A61K39/464499 , A61P35/00 , C07K14/7051 , C12N5/0636 , C12N15/1024 , C12N15/86 , A61K2239/26 , C12N2510/00 , C12N2740/10043

摘要： Construction of a T cell receptor and the use thereof are provided. Utilizing mutations of intracellular constant region sites of an α chain and an β chain of the T cell receptor to inhibit the degradation of the T cell receptor after TCR antigen signal activation, maintain the level of TCR on cell surface, and improve the efficacy of TCR-T cell therapy. This method can be applied to different TCR-T cell therapies.