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公开(公告)号:US10100044B2
公开(公告)日:2018-10-16
申请号:US15030331
申请日:2014-10-20
申请人: SUZHOU VIGONVITA LIFE SCIENCES CO., LTD. , TOPHARMAN SHANGHAI CO., LTD. , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人: Zheng Liu , Chunhui Wu , Yongjian Liu , Rongxia Zhang , Yang He , Guanghui Tian , Jingshan Shen
IPC分类号: C07D333/70 , C07D409/12 , C07D333/54
摘要: The present invention relates to the methods for preparing brexpiprazole, the analogs, key intermediates, and salts thereof, specifically, the present invention relates to a new method for preparing brexpiprazole, the analogs, key intermediates, and salts thereof, and the key intermediates, and salts thereof provided during the preparation. The preparation method has a mild reaction condition, stable intermediate, easy operation, and uses cheap and easy-to-get reagents, thus it saves the synthesis cost, shortens the production cycle, improves the yield and product quality, and is suitable for mass production.
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公开(公告)号:US10174011B2
公开(公告)日:2019-01-08
申请号:US15124264
申请日:2015-03-09
申请人: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES , SUZHOU VIGONVITA LIFE SCIENCES CO., LTD. , TOPHARMAN SHANDONG CO., LTD.
发明人: Hualiang Jiang , Zhen Wang , Jianfeng Li , Rongxia Zhang , Yang He , Yongjian Liu , Minghao Bi , Zheng Liu , Guanghui Tian , Weiming Chen , Feipu Yang , Chunhui Wu , Yu Wang , Xiangrui Jiang , Jingjing Yin , Guan Wang , Jingshan Shen
IPC分类号: C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D519/00 , A61K31/496 , A61K31/519 , A61K31/4709 , A61K31/517 , A61K31/538 , A61K31/5415 , A61K31/55
摘要: The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease.
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