公开(公告)号：US12065449B2

公开(公告)日：2024-08-20

申请号：US18547958

申请日：2022-02-24

Applicant: SYNESIS LLC

Inventor： Jess D. Reed ,  Daniel Alfredo Esquivel-Alvarado ,  Emilia Alfaro-Viquez ,  Christian G. Krueger

IPC: A61K9/20 ,  A61K9/00 ,  A61K9/06 ,  A61K9/12 ,  A61K9/48 ,  C07D519/00 ,  G01N33/569

CPC classification number: C07D519/00 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/124 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  G01N33/56916 ,  G01N2333/245 ,  G01N2469/10

Abstract: Proanthocyanidin-cinnamaldehydes pyrylium products (FP) were synthesized by the condensation reaction of proanthocyanidins (PAC) with various cinnamaldehydes. Synthesized FP exhibited fluorescence at higher excitation and emission wavelengths than PAC. FP were evaluated for their ability to agglutinate extra-intestinal pathogenic Escherichia coli (ExPEC). Results showed that FP were significantly more bioactive (p-value