公开(公告)号：US20240245792A1

公开(公告)日：2024-07-25

申请号：US18525282

申请日：2023-11-30

Applicant: Synthorx, Inc. ,  MSD INTERNATIONAL GMBH ,  MSD INTERNATIONAL BUSINESS GMBH

Inventor： Giovanni Abbadessa ,  Carolina E. Caffaro ,  Brigitte Demers ,  Joseph Leveque ,  Wan-Ju Meng ,  Marcos Milla ,  Jerod Ptacin

IPC: A61K47/64 ,  A61K39/00 ,  A61P35/04 ,  C07K16/22 ,  C07K16/28

CPC classification number: A61K47/642 ,  A61P35/04 ,  C07K16/22 ,  C07K16/2818 ,  C07K16/2863 ,  A61K2039/507

Abstract: Disclosed herein are methods for treating head and neck squamous cell carcinoma (HNSCC) in a subject in need thereof, comprising administering IL-2 conjugates in combination with one or more additional agents.

公开(公告)号：US20230381335A1

公开(公告)日：2023-11-30

申请号：US18447808

申请日：2023-08-10

Applicant: SYNTHORX, INC. ,  MSD INTERNATIONAL GMBH

Inventor： Giovanni Abbadessa ,  Carolina E. Caffaro ,  Brigitte Demers ,  Joseph Leveque ,  Wan-Ju Meng ,  Jerod Ptacin

IPC: A61K47/68 ,  C07K16/28 ,  C07K16/24 ,  A61K31/282 ,  A61K33/243 ,  A61P35/00 ,  A61K31/337 ,  A61K31/167 ,  A61K31/138

CPC classification number: A61K47/6845 ,  C07K16/2818 ,  C07K16/246 ,  A61K31/282 ,  A61K33/243 ,  A61P35/00 ,  A61K31/337 ,  A61K31/167 ,  A61K31/138

Abstract: Disclosed herein are methods for treating a lung cancer in a subject in need thereof, comprising administering IL-2 conjugates in combination with the anti-PD-1 antibody or antigen-binding fragment thereof (e.g., pembrolizumab).