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公开(公告)号:US20090298804A1
公开(公告)日:2009-12-03
申请号:US12294267
申请日:2007-03-30
申请人: Sabine Gaisser , Christine Martin , Ming Zhang , Barrie Wilkinson , Nigel Coates , Mohammed Nur-E-Alam , Nikolaos Galtatzis
发明人: Sabine Gaisser , Christine Martin , Ming Zhang , Barrie Wilkinson , Nigel Coates , Mohammed Nur-E-Alam , Nikolaos Galtatzis
IPC分类号: A61K31/33 , C07D225/06 , C12P17/10 , C12N1/21
CPC分类号: C07D225/06
摘要: The present invention relates to 15-desmethoxymacbecin analogues that are useful, e.g. in the treatment of cancer, B-cell malignancies malaria, fungal infection, diseases of the central nervous system and neurodegenerative diseases, diseases dependent on angiogenesis, autoimmune diseases and/or as a prophylactic pretreatment for cancer. The present invention also provides methods for the production of these compounds and their use in medicine, in particular in the treatment and/or prophylaxis of cancer or B-cell malignancies.
摘要翻译: 本发明涉及15-脱甲氧基锍类似物,其可用于,例如, 在治疗癌症,B细胞恶性疟疾,真菌感染,中枢神经系统疾病和神经变性疾病,依赖于血管生成的疾病,自身免疫疾病和/或作为癌症的预防性预处理。 本发明还提供了这些化合物的制备方法及其在医药中的用途,特别是用于治疗和/或预防癌症或B细胞恶性肿瘤的方法。