公开(公告)号：US20230399357A1

公开(公告)日：2023-12-14

申请号：US18455324

申请日：2023-08-24

Applicant: Sage Therapeutics, Inc.

Inventor： Paul Steven Watson ,  Bret Berner ,  John Gregory Reid ,  Jian Wang ,  James J. Doherty ,  Stephen Jay Kanes

IPC: C07J43/00 ,  C07D231/14 ,  A61P37/00 ,  A61P25/22 ,  A61P25/18 ,  A61P25/24 ,  A61P25/00 ,  A61P25/08

CPC classification number: C07J43/003 ,  C07D231/14 ,  A61P37/00 ,  A61P25/22 ,  A61P25/18 ,  A61P25/24 ,  A61P25/00 ,  A61P25/08 ,  C07B2200/13

Abstract: This invention relates to a crystalline 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I),




and compositions thereof. Also disclosed herein are methods of making the same and methods of using the same.

公开(公告)号：US20190177359A1

公开(公告)日：2019-06-13

申请号：US16326977

申请日：2017-08-23

Applicant: Sage Therapeutics, Inc.

Inventor： Paul Steven Watson ,  Bret Berner ,  John Gregory Reid ,  Jian Wang ,  James J. Doherty ,  Stephen Jay Kanes

IPC: C07J43/00 ,  A61P25/00 ,  A61P37/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24

Abstract: This invention relates to a 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) and crystalline solid forms and compositions thereof. Also disclosed herein are methods of making crystalline solid forms of the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) and methods of using the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) or crystalline solid forms, pharmaceutically acceptable salts, and pharmaceutically acceptable compositions thereof.

公开(公告)号：US20220169674A1

公开(公告)日：2022-06-02

申请号：US17396464

申请日：2021-08-06

Applicant: Sage Therapeutics, Inc.

Inventor： Paul Steven Watson ,  Bret Berner ,  John Gregory Reid ,  Jian Wang ,  James J. Doherty ,  Stephen Jay Kanes

IPC: C07J43/00 ,  C07D231/14 ,  A61P37/00 ,  A61P25/22 ,  A61P25/18 ,  A61P25/24 ,  A61P25/00 ,  A61P25/08

Abstract: This invention relates to a crystalline 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I), and compositions thereof. Also disclosed herein are methods of making the same and methods of using the same.

公开(公告)号：US11236121B2

公开(公告)日：2022-02-01

申请号：US16326977

申请日：2017-08-23

Applicant: Sage Therapeutics, Inc.

Inventor： Paul Steven Watson ,  Bret Berner ,  John Gregory Reid ,  Jian Wang ,  James J. Doherty ,  Stephen Jay Kanes

IPC: C07J43/00 ,  C07D231/14 ,  A61P37/00 ,  A61P25/22 ,  A61P25/18 ,  A61P25/24 ,  A61P25/00 ,  A61P25/08

Abstract: This invention relates to a 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) and crystalline solid forms and compositions thereof. Also disclosed herein are methods of making crystalline solid forms of the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) and methods of using the 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I) or crystalline solid forms, pharmaceutically acceptable salts, and pharmaceutically acceptable compositions thereof.

公开(公告)号：US11884696B2

公开(公告)日：2024-01-30

申请号：US17396464

申请日：2021-08-06

Applicant: Sage Therapeutics, Inc.

Inventor： Paul Steven Watson ,  Bret Berner ,  John Gregory Reid ,  Jian Wang ,  James J. Doherty ,  Stephen Jay Kanes

IPC: C07J43/00 ,  C07D231/14 ,  A61P25/22 ,  A61P25/18 ,  A61P25/24 ,  A61P25/00 ,  A61P25/08 ,  A61P37/00

CPC classification number: C07J43/003 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P37/00 ,  C07D231/14 ,  C07B2200/13

Abstract: This invention relates to a crystalline 19-nor C3,3-disubstituted C21-pyrazolyl steroid of Formula (I),




and compositions thereof. Also disclosed herein are methods of making the same and methods of using the same.