公开(公告)号：US20210009709A1

公开(公告)日：2021-01-14

申请号：US16977572

申请日：2019-03-04

申请人： SAITAMA MEDICAL UNIVERSITY ,  DAIICHI SANKYO COMPANY, LIMITED

发明人： Takenobu KATAGIRI ,  Sho TSUKAMOTO ,  Keigo KUMAGAI ,  Shinnosuke TSUJI

IPC分类号： C07K16/28 ,  C12Q1/6827

摘要： This application relates to a pharmaceutical composition for use in a method for treating and/or preventing a patient having ectopic ossification and/or brain tumor, wherein the patient has an active mutation in ALK2 protein which is responsible for ectopic ossification or brain tumor; an amino acid residue at position 330 of ALK2 is proline; and an active ingredient of this composition is an anti-ALK2 antibody or an antigen-binding fragment thereof comprising a property of binding to ALK2, a property of cross-linking ALK2, and a property of inhibiting BMP signal transduction.

公开(公告)号：US20220267453A1

公开(公告)日：2022-08-25

申请号：US17629715

申请日：2020-07-22

申请人： Saitama Medical University ,  Daiichi Sankyo Company, Limited

发明人： Takenobu KATAGIRI ,  Sho TSUKAMOTO ,  Mai KURATANI

IPC分类号： C07K16/28

摘要： This application provides: an antibody or an antigen-binding fragment thereof which can be used not only as a therapeutic drug but as a tool of immunological and immunohistological analysis such as immunostaining or Western blot, specifically recognizes an extracellular region polypeptide of human, mouse and rat ALK2, and inhibits BMP signal transduction, and an antibody or an antigen-binding fragment thereof which has a property of specifically binding to an extracellular region of ALK2 to form an ALK2 homodimer and a property of inhibiting the formation of an ALK2-type II receptor heterodimer, and inhibits the activation of ALK2 kinase, or inhibits BMP signal transduction; and a method for inhibiting the activation of ALK2 kinase or a method for inhibiting BMP signal transduction using the antibody or the antigen-binding fragment thereof.

公开(公告)号：US20180118835A1

公开(公告)日：2018-05-03

申请号：US15547231

申请日：2016-01-29

申请人： Saitama Medical University ,  Daiichi Sankyo Company, Limited

发明人： Takenobu Katagiri ,  Kenji OSAWA ,  Sho TSUKAMOTO ,  Shinnosuke TSUJI ,  Yoshirou KAWAGUCHI ,  Kensuke NAKAMURA

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P19/08 ,  A61P7/06 ,  A61P35/00

CPC分类号： C07K16/2863 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61P7/06 ,  A61P19/08 ,  A61P35/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92

摘要： This application provides: an antibody which specifically binds to an ALK2 protein and has an activity of inhibiting BMP signal transduction mediated by ALK2; a method for producing the antibody; and a pharmaceutical composition comprising the antibody, for treating and/or preventing ectopic ossification and/or bone dysplasia, anemia, or diffuse intrinsic pontine glioma (DIPG).