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公开(公告)号：US07432293B2
公开(公告)日：2008-10-07
申请号：US10545245
申请日：2004-02-13
IPC分类号： A61K31/42 , A61K31/4245 , C07D263/30 , C07D271/06
CPC分类号： C07D271/06 , C07D261/08 , C07D263/32 , C07D413/04
摘要： The present invention relates to compounds of formula (I): wherein R1 is hydroxy, C1-4 alkoxy, amino, C1-4 alkyl-amino, di C1-4alkylamino, benzyloxy or C2-C7 alkanoyl, R2 is C1-4 alkyl, C1-4 alkoxy, C1-4 alkoxy C1-4alkoxy, CF3, halogen, C1-4alkylamino, di C1-4alkylamino, di C1-4 alkylamino C1-4 alkoxy or N—C1-4 alkoxy C1-4 alkyl-N—C1-4 alkylamino, N—C1-4 alkyl-piperazinyl, morpholinyl or pyrrolidinyl-C1-4 alkoxy, wherein the C1-4 alkyl radicals in R2 are optionally further substituted by C1-4 alkyl, halogen, cyano, amino, alkoxy or alkylthio, X is N or O, Y is N, O or CH, Z is N or CH, and W is N or CH, provided that (a) R1 is not hydroxy or C1-4 alkoxy when R2 is CF3, X is O, Y is CH, Z is N and W is CH, (b) R1 is not hydroxy or C1-4 alkoxy when R2 is CF3 or chloro, X is N, Y is O, Z is CH and W is CH, (c) R1 is not hydroxy when R2 is CF3, X is O, Y is N, Z is CH and W is CH and (d) X and Y are not simultaneously O, the salts thereof; their preparation, their use and pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的化合物：其中R 1是羟基，C 1-4烷氧基，氨基，C 1-4 烷基 - 氨基，二C 1-4烷基氨基，苄氧基或C 2 -C 7烷酰基，R 2 为C 1-4烷基，C 1-4烷氧基，C 1-4烷氧基C 1-4烷基 烷氧基，CF 3，卤素，C 1-4烷基氨基，二C 1-4烷基氨基，二C 1-4 烷基氨基C 1-4烷氧基或NC 1-4烷氧基C 1-4烷基-NC 1-4 烷基氨基，NC 1-4烷基 - 哌嗪基，吗啉基或吡咯烷基-C 1-4烷氧基，其中C 1-4 - R 2中的烷基任选进一步被C 1-4烷基，卤素，氰基，氨基，烷氧基或烷硫基取代，X是N或O，Y是N ，O或CH，Z是N或CH，W是N或CH，条件是当R（R）不为羟基或C 1-4烷氧基时， 2是CF 3，X是O，Y是C H，Z是N，W是CH，（b）当R 2是CF时，R 1不是羟基或C 1-4烷氧基 3是或氯，X是N，Y是O，Z是CH，W是CH，（c）R 1不是羟基， SUB>是CF 3，X是O，Y是N，Z是CH，W是CH，（d）X和Y不同时为O，其盐; 它们的制备，它们的用途和含有它们的药物组合物。
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公开(公告)号：US20060089365A1
公开(公告)日：2006-04-27
申请号：US10545245
申请日：2004-02-13
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4439 , A61K31/4245 , A61K31/4196 , C07D413/14 , C07D403/14
CPC分类号： C07D271/06 , C07D261/08 , C07D263/32 , C07D413/04
摘要： The present invention relates to compounds of formula (I): wherein R1 is hydroxy, C1-4 alkoxy, amino, C1-4 alkyl-amino, di C1-4alkylamino, benzyloxy or C2-C7 alkanoyl, R2 is C1-4 alkyl, C1-4 alkoxy, C1-4 alkoxy C1-4alkoxy, CF3, halogen, C1-4alkylamino, di C1-4alkylamino, di C1-4 alkylamino C1-4 alkoxy or N—C1-4 alkoxy C1-4 alkyl-N—C1-4 alkylamino, N—C1-4 alkyl-piperazinyl, morpholinyl or pyrrolidinyl-C1-4 alkoxy, wherein the C1-4 alkyl radicals in R2 are optionally further substituted by C1-4 alkyl, halogen, cyano, amino, alkoxy or alkylthio, X is N or O, Y is N, O or CH, Z is N or CH, and W is N or CH, provided that (a) R1 is not hydroxy or C1-4 alkoxy when R2 is CF3, X is O, Y is CH, Z is N and W is CH, (b) R1 is not hydroxy or C1-4 alkoxy when R2 is CF3 or chloro, X is N, Y is O, Z is CH and W is CH, (c) R1 is not hydroxy when R2 is CF3, X is O, Y is N, Z is CH and W is CH and (d) X and Y are not simultaneously O, the salts thereof; their preparation, their use and pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的化合物：其中R 1是羟基，C 1-4烷氧基，氨基，C 1-4 烷基 - 氨基，二C 1-4烷基氨基，苄氧基或C 2 -C 7烷酰基，R 2 为C 1-4烷基，C 1-4烷氧基，C 1-4烷氧基C 1-4烷基 烷氧基，CF 3，卤素，C 1-4烷基氨基，二C 1-4烷基氨基，二C 1-4 烷基氨基C 1-4烷氧基或NC 1-4烷氧基C 1-4烷基-NC 1-4 烷基氨基，NC 1-4烷基 - 哌嗪基，吗啉基或吡咯烷基-C 1-4烷氧基，其中C 1-4 - R 2中的烷基任选进一步被C 1-4烷基，卤素，氰基，氨基，烷氧基或烷硫基取代，X是N或O，Y是N ，O或CH，Z是N或CH，W是N或CH，条件是当R（R）不为羟基或C 1-4烷氧基时， 2是CF 3，X是O，Y是C H，Z是N，W是CH，（b）当R 2是CF时，R 1不是羟基或C 1-4烷氧基 3是或氯，X是N，Y是O，Z是CH，W是CH，（c）R 1不是羟基， SUB>是CF 3，X是O，Y是N，Z是CH，W是CH，（d）X和Y不同时为O，其盐; 它们的制备，它们的用途和含有它们的药物组合物。
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公开(公告)号：US07087756B2
公开(公告)日：2006-08-08
申请号：US10486569
申请日：2002-08-14
IPC分类号： C07D471/02
CPC分类号： C07D498/04
摘要： The invention provides compounds of formula I, wherein X, Y, R1, R2, and R3 are as defined in the description, and the preparation thereof. The compounds of formula I are useful as pharmaceuticals.
摘要翻译： 本发明提供式I化合物，其中X，Y，R 1，R 2和R 3是如说明书中所定义的， 及其制备。 式I的化合物可用作药物。
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