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公开(公告)号：US08513429B2
公开(公告)日：2013-08-20
申请号：US13367612
申请日：2012-02-07
申请人： Samuel J. Danishefsky , Alexey Rivkin , Yoshimura Fumikiko , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
发明人： Samuel J. Danishefsky , Alexey Rivkin , Yoshimura Fumikiko , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
IPC分类号： C07D493/04 , C07D417/06
CPC分类号： C07D413/06 , C07D313/00 , C07D417/02 , C07D417/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
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2.发明申请公开(公告)号：US20120316348A1
公开(公告)日：2012-12-13
申请号：US13367612
申请日：2012-02-07
申请人： Samuel J. Danishefsky , Alexey Rivkin , Yoshimura Fumikiko , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
发明人： Samuel J. Danishefsky , Alexey Rivkin , Yoshimura Fumikiko , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
IPC分类号： C07D493/04 , C07F7/08 , C07D417/06
CPC分类号： C07D413/06 , C07D313/00 , C07D417/02 , C07D417/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
摘要翻译： 本发明提供式（I）化合物：如本文中一般性地和类别和亚类所述。 本发明还提供包含式（I）化合物的药物组合物，并提供治疗癌症的方法，包括施用式（I）化合物。
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3.发明申请公开(公告)号：US20100197746A1
公开(公告)日：2010-08-05
申请号：US12604127
申请日：2009-10-22
申请人： Samuel J. Danishefsky , Alexey Rivkin , Yoshimura Fumikiko , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
发明人： Samuel J. Danishefsky , Alexey Rivkin , Yoshimura Fumikiko , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
IPC分类号： A61K31/427 , A61P35/00
CPC分类号： C07D413/06 , C07D313/00 , C07D417/02 , C07D417/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
摘要翻译： 本发明提供式（I）化合物：如本文中一般性地和类别和亚类所述。 本发明还提供包含式（I）化合物的药物组合物，并提供治疗癌症的方法，包括施用式（I）化合物。
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公开(公告)号：US08110590B2
公开(公告)日：2012-02-07
申请号：US12604127
申请日：2009-10-22
申请人： Samuel J. Danishefsky , Alexey Rivkin , Yoshimura Fumikiko , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
发明人： Samuel J. Danishefsky , Alexey Rivkin , Yoshimura Fumikiko , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
IPC分类号： A61K31/427
CPC分类号： C07D413/06 , C07D313/00 , C07D417/02 , C07D417/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
摘要翻译： 本发明提供式（I）化合物：如本文中一般性地和类别和亚类所述。 本发明还提供包含式（I）化合物的药物组合物，并提供治疗癌症的方法，包括施用式（I）化合物。
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公开(公告)号：US07649006B2
公开(公告)日：2010-01-19
申请号：US10435408
申请日：2003-05-09
申请人： Samuel J. Danishefsky , Alexey Rivkin , Yoshimura Fumikiko , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
发明人： Samuel J. Danishefsky , Alexey Rivkin , Yoshimura Fumikiko , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
IPC分类号： A61K31/427
CPC分类号： C07D413/06 , C07D313/00 , C07D417/02 , C07D417/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
摘要翻译： 本发明提供式（I）化合物：如本文中一般性地和类别和亚类所述。 本发明还提供包含式（I）化合物的药物组合物，并提供治疗癌症的方法，包括施用式（I）化合物。
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公开(公告)号：US07759374B2
公开(公告)日：2010-07-20
申请号：US11546715
申请日：2006-10-12
申请人： Samuel J. Danishefsky , Alexey Rivkin , Fumikiko Yoshimura , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
发明人： Samuel J. Danishefsky , Alexey Rivkin , Fumikiko Yoshimura , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong
IPC分类号： A61K31/427 , A61K31/422 , A61K31/42 , C07D277/20 , C07D263/30 , C07D261/06
CPC分类号： C07D413/06 , C07D313/00 , C07D417/02 , C07D417/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
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7.发明授权Synthesis of epothilones, intermediates thereto, analogues and uses thereof 有权埃坡霉素的合成，其中间体，其类似物及其用途公开(公告)号：US07875638B2
公开(公告)日：2011-01-25
申请号：US12135823
申请日：2008-06-09
申请人： Samuel J. Danishefsky , Alexey Rivkin , Fumihiko Yoshimura , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong , Kaida Wu , Malcolm A. S. Moore , David Dorn
发明人： Samuel J. Danishefsky , Alexey Rivkin , Fumihiko Yoshimura , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong , Kaida Wu , Malcolm A. S. Moore , David Dorn
IPC分类号： A61K31/427 , C07D417/06
CPC分类号： C07D417/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
摘要翻译： 本发明提供式（I）化合物：如本文中一般性地和类别和亚类所述。 本发明还提供包含式（I）化合物的药物组合物，并提供治疗癌症的方法，包括施用式（I）化合物。
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8.发明授权Synthesis of epothilones, intermediates thereto, analogues and uses thereof 有权埃坡霉素的合成，其中间体，其类似物及其用途公开(公告)号：US07384964B2
公开(公告)日：2008-06-10
申请号：US10921109
申请日：2004-08-18
申请人： Samuel J. Danishefsky , Alexey Rivkin , Fumihiko Yoshimura , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong , Kaida Wu , Malcolm A. S. Moore , David Dorn
发明人： Samuel J. Danishefsky , Alexey Rivkin , Fumihiko Yoshimura , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong , Kaida Wu , Malcolm A. S. Moore , David Dorn
IPC分类号： A61K31/428 , A61K31/427 , A61K31/422 , A61K31/423 , C07D417/04 , C07D413/04 , C07D417/06
CPC分类号： C07D417/06 , C07D413/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
摘要翻译： 本发明提供式（I）化合物：如本文中一般性地和类别和亚类所述。 本发明还提供包含式（I）化合物的药物组合物，并提供治疗癌症的方法，包括施用式（I）化合物。
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9.发明申请公开(公告)号：US20090149516A1
公开(公告)日：2009-06-11
申请号：US12135823
申请日：2008-06-09
申请人： Samuel J. Danishefsky , Alexey Rivkin , Fumihiko Yoshimura , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong , Kaida Wu , Malcolm A.S. Moore , David Dorn
发明人： Samuel J. Danishefsky , Alexey Rivkin , Fumihiko Yoshimura , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong , Kaida Wu , Malcolm A.S. Moore , David Dorn
IPC分类号： A61K31/427 , C07D417/06 , A61P35/00
CPC分类号： C07D417/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
摘要翻译： 本发明提供式（I）化合物：如本文中一般性地和类别和亚类所述。 本发明还提供包含式（I）化合物的药物组合物，并提供治疗癌症的方法，包括施用式（I）化合物。
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公开(公告)号：US06921769B2
公开(公告)日：2005-07-26
申请号：US10402004
申请日：2003-03-28
IPC分类号： C07D417/06 , C07D493/04 , A61K31/427 , C07D272/22
CPC分类号： C07D417/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
摘要翻译： 本发明提供式（I）化合物：如本文中一般性地和类别和亚类所述。 本发明还提供包含式（I）化合物的药物组合物，并提供治疗癌症的方法，包括施用式（I）化合物。
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