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公开(公告)号:US20060116332A1
公开(公告)日:2006-06-01
申请号:US11266033
申请日:2005-11-02
申请人: Samuel Strober , Everett Meyer , Dale Umetsu
发明人: Samuel Strober , Everett Meyer , Dale Umetsu
IPC分类号: A61K31/7024
CPC分类号: A61K31/164 , A61K31/19 , A61K31/70 , A61K31/7024 , A61K31/7028
摘要: Molecules that interact with the NKT cell antigen receptor and its counterpart antigen presenting molecule, but which inhibit the NKT cell immune function, are administered to a patient. Conditions of particular interest include the treatment of systemic lupus erythematosus (SLE), cancer, atherosclerosis, and allergic disease. In some embodiment of the invention, the inhibitory agent is an anergizing glycolipid, for example β-galactosylceramide. Pharmaceutical formulations of such glycolipids are provided, and find use in the treatment of diseases involving undesirable NKT cell activation.
摘要翻译: 与NKT细胞抗原受体和其对应的抗原呈递分子相互作用,但抑制NKT细胞免疫功能的分子被施用于患者。 特别感兴趣的病症包括治疗系统性红斑狼疮(SLE),癌症,动脉粥样硬化和过敏性疾病。 在本发明的一些实施方案中,抑制剂是去电糖脂,例如β-半乳糖神经酰胺。 提供了这种糖脂的药物制剂,并且可用于治疗涉及不期望的NKT细胞活化的疾病。
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公开(公告)号:US20090066499A1
公开(公告)日:2009-03-12
申请号:US12166280
申请日:2008-07-01
申请人: Yun Bai , Everett Meyer
发明人: Yun Bai , Everett Meyer
IPC分类号: B60Q1/00
摘要: An external sound generating system and method are provided that can be used to generate an external sound for quiet vehicles such as hybrid vehicle, an electric motor vehicle or a fuel cell vehicle.
摘要翻译: 提供了可用于产生诸如混合动力车辆,电动车辆或燃料电池车辆之类的安静车辆的外部声音的外部声音产生系统和方法。
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