公开(公告)号：US20160287688A1

公开(公告)日：2016-10-06

申请号：US15095360

申请日：2016-04-11

申请人： SANARIA INC.

发明人： Abraham G. EAPPEN ,  Stephen L. HOFFMAN

IPC分类号： A61K39/015 ,  C12N1/10

CPC分类号： A61K39/015 ,  A61K2039/52 ,  A61K2039/522 ,  C12N1/10 ,  Y02A50/412

摘要： The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. Provided herein are in vitro-reared infectious Plasmodium sporozoites (SPZ) of human host range, particularly P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi, wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same.

摘要翻译： 该应用涉及人宿主范围的体外培养的疟原虫子孢子，其中从配子细胞阶段到子孢子期的孢子体在蚊子外部，以及其生产方法。 本文提供的是人宿主范围的体外培养的感染性疟原虫子孢子（SPZ），特别是恶性疟原虫，间日疟原虫，卵白念珠菌，疟原虫和know know属，其中从配子细胞阶段到子孢子期的孢子是外部的 蚊子，以及生产蚊子的方法。

公开(公告)号：US20220257742A1

公开(公告)日：2022-08-18

申请号：US17529812

申请日：2021-11-18

申请人： Sanaria Inc.

发明人： Abraham G. EAPPEN ,  Stephen L. HOFFMAN

IPC分类号： A61K39/015 ,  C12N1/10

摘要： The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. Provided herein are in vitro-reared infectious Plasmodium sporozoites (SPZ) of human host range, particularly P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi, wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same.

公开(公告)号：US20240173393A1

公开(公告)日：2024-05-30

申请号：US18532731

申请日：2023-12-07

申请人： Sanaria Inc.

发明人： Abraham G. EAPPEN ,  Stephen L. HOFFMAN

IPC分类号： A61K39/015 ,  A61K39/00 ,  C12N1/10

CPC分类号： A61K39/015 ,  C12N1/10 ,  A61K2039/52 ,  A61K2039/522 ,  Y02A50/30

摘要： The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. Provided herein are in vitro-reared infectious Plasmodium sporozoites (SPZ) of human host range, particularly P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi, wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same.

公开(公告)号：US20180161413A1

公开(公告)日：2018-06-14

申请号：US15858574

申请日：2017-12-29

申请人： SANARIA INC.

发明人： Abraham G. EAPPEN ,  Stephen L. HOFFMAN

IPC分类号： A61K39/015 ,  C12N1/10 ,  A61K39/00

CPC分类号： A61K39/015 ,  A61K2039/52 ,  A61K2039/522 ,  C12N1/10 ,  Y02A50/412

摘要： The application is directed to in vitro-reared Plasmodium sporozoites of human host range wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same. Provided herein are in vitro-reared infectious Plasmodium sporozoites (SPZ) of human host range, particularly P. falciparum, P. vivax, P. ovale, P. malariae, and P. knowlesi, wherein sporogony from gametocyte stage to sporozoite stage is external to mosquitoes, and methods of producing the same.