公开(公告)号：US20160175417A1

公开(公告)日：2016-06-23

申请号：US15002443

申请日：2016-01-21

申请人： Sanaria Inc.

发明人： B. Kim Lee SIM ,  Minglin LI ,  Richard E. STAFFORD ,  Stephen L. HOFFMAN

IPC分类号： A61K39/015

CPC分类号： A61K39/015 ,  A61K9/0019 ,  A61K31/4706 ,  A61K2039/522 ,  A61K2039/6081 ,  Y02A50/412

摘要： Disclosed are substantially purified Plasmodium sporozoites and preparations of Plasmodium sporozoites substantially separated from attendant non-sporozoite material, where the preparations of Plasmodium sporozoites have increasing levels of purity. Vaccines and pharmaceutical compositions comprising purified Plasmodium sporozoites are likewise provided. Methods of purifying preparations of Plasmodium sporozoites are also provided.

公开(公告)号：US20150313981A1

公开(公告)日：2015-11-05

申请号：US14671003

申请日：2015-03-27

申请人： Sanaria Inc.

发明人： B. Kim Lee SIM ,  Minglin LI ,  Richard E. STAFFORD ,  Stephen L. Hoffman

IPC分类号： A61K39/015 ,  A61K9/00

CPC分类号： A61K39/015 ,  A61K9/0019 ,  A61K31/4706 ,  A61K2039/522 ,  A61K2039/6081 ,  Y02A50/412

摘要： Disclosed are substantially purified Plasmodium sporozoites and preparations of Plasmodium sporozoites substantially separated from attendant non-sporozoite material, where the preparations of Plasmodium sporozoites have increasing levels of purity. Vaccines and pharmaceutical compositions comprising purified Plasmodium sporozoites are likewise provided. Methods of purifying preparations of Plasmodium sporozoites are also provided.

摘要翻译： 公开了基本上纯化的疟原虫子孢子和与伴随的非子孢子物质基本分离的疟原虫子孢子的制剂，其中疟原虫子孢子的制剂具有提高的纯度。 同样提供包含纯化的疟原虫子孢子的疫苗和药物组合物。 还提供了提纯疟原虫子孢子的制备方法。