专利检索 ap:("Sandeep Gupta" OR "Pradeep Banerjee" OR "Debomoy Lahiri" OR "Martin Farlow") AND inv:"Debomoy Lahiri" 第 1 页

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发明申请
Use of 1-aminocyclohexane derivatives to modify deposition of fibrillogenic a-beta peptides in amyloidopathies 审中-公开
标题翻译：使用1-氨基环己烷衍生物改变淀粉样蛋白病中纤维蛋白原α-β肽的沉积

公开(公告)号：US20050113458A1

公开(公告)日：2005-05-26

申请号：US10971306

申请日：2004-10-22

申请人： Sandeep Gupta , Pradeep Banerjee , Debomoy Lahiri , Martin Farlow

发明人： Sandeep Gupta , Pradeep Banerjee , Debomoy Lahiri , Martin Farlow

IPC分类号： A61K31/13

CPC分类号： A61K31/13

摘要： The invention relates to the use of NMDA receptor antagonists such as 1-aminocyclohexane derivatives to modify deposition of potentially toxic and fibrillogenic Aβ peptides in amyloidopathies. Specifically, the invention relates to the ability of memantine to intervene in the processing of APP and decrease the levels of fibrillogenic Aβ peptides.

摘要翻译： 本发明涉及NMDA受体拮抗剂如1-氨基环己烷衍生物在淀粉样蛋白病中改变潜在毒性和原纤维化Aβ肽的沉积的用途。具体地说，本发明涉及美金刚介入APP的加工和降低纤维蛋白原Aβ肽水平的能力。