公开(公告)号：US20120010823A1

公开(公告)日：2012-01-12

申请号：US13135466

申请日：2011-07-06

申请人： Sandy C. Shaw

发明人： Sandy C. Shaw

IPC分类号： G01N33/483 ,  G06F19/20

CPC分类号： G16H50/20 ,  G16B25/00

摘要： A device, method and system are provided for diagnosing a disease using a gene expression reader to analyze biological samples and output gene expression values to calculate a scaling factor using a computer by counting a number of link counts Cn for groups of an individual genes' expression values at different times at a threshold value C or for groups of genes' expression values at a single time at the threshold value C, calculating an average number Cave of the link counts Cn, calculating a largest number M of the Cn, iteratively applying a relation Cave=M/log(M) for different threshold values C, comparing data of the Cave values versus M/log(M), and calculating a fitting to the compared data to output the scaling factor a. The scaling factor a is compared with other scaling factors a′ in a database to output a report of estimates for a degree of health.

摘要翻译： 提供了一种用于使用基因表达读数器诊断疾病的装置，方法和系统，以分析生物样品并输出基因表达值，以通过计算个体基因表达组的多个连锁计数Cn来计算缩放因子 在阈值C处的不同时间的值或在阈值C处的单个时间的基因表达值组，计算链接计数Cn的平均数Cave，计算Cn的最大数量M，迭代地应用 关系Cave = M / log（M）对于不同的阈值C，比较洞值与M / log（M）的数据，并计算与比较数据的拟合以输出比例因子a。 将比例因子a与数据库中的其他比例因子a'进行比较，以输出健康程度的估计报告。

公开(公告)号：US07366719B2

公开(公告)日：2008-04-29

申请号：US10959844

申请日：2004-10-06

申请人： Sandy C. Shaw

发明人： Sandy C. Shaw

IPC分类号： G06F7/00 ,  G06F9/30

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  G06F19/12 ,  G06F19/18 ,  G06F19/20 ,  G06F19/22 ,  G06F19/24 ,  G06F19/26 ,  Y10S707/99931 ,  Y10S707/99936 ,  Y10S707/99937

摘要： There is described a method for manipulation, storage, modeling, visualization, and quantification of datasets, which correspond to target strings. An iterative algorithm is used to generate comparison strings corresponding to some set of points that can serve as the domain of an iterative function. The comparison string is scored by evaluating a function having the comparison string and one of the plurality of target strings as inputs. The score measures a relationship between a comparison string and a target string. The evaluation may be repeated for a number of the other target strings. The score or some other property corresponding to the comparison string is used to determine the target string's placement on a map. The target string may also be marked by a point on a visual display.

摘要翻译： 描述了对应于目标字符串的数据集的操纵，存储，建模，可视化和量化的方法。 使用迭代算法来生成对应于可以用作迭代函数的域的某些点的比较串。 通过评估具有比较串和多个目标串中的一个作为输入的功能来对比较串进行评分。 分数测量比较字符串和目标字符串之间的关系。 对于多个其他目标串可以重复评估。 对应于比较字符串的得分或其他属性用于确定目标字符串在地图上的位置。 目标字符串也可以由可视显示器上的点标记。

公开(公告)号：US06920451B2

公开(公告)日：2005-07-19

申请号：US09766247

申请日：2001-01-19

申请人： Sandy C. Shaw

发明人： Sandy C. Shaw

IPC分类号： G06F17/30

CPC分类号： G06F17/30713 ,  Y10S707/99936 ,  Y10S707/99943 ,  Y10S707/99945

摘要： There is described a method for manipulation, storage, modeling, visualization, and quantification of datasets, which correspond to target strings. A number of target strings are provided. An iterative algorithm is used to generate comparison strings corresponding to some set of points that can serve as the domain of an iterative function. Preferably these points are located in the complex plane, such as in and/or near the Mandelbrot Set or a Julia Set. These comparison strings are also datasets. The comparison string is scored by evaluating a function having the comparison string and one of the plurality of target strings as inputs. The score measures a relationship between a comparison string and a target string. The evaluation may be repeated for a number of the other target strings. The score or some other property corresponding to the comparison string is used to determine the target string's placement on a map. The target string may also be marked by a point on a visual display. The coordinates of the point corresponding to the target string or properties of the comparison string may be stored in memory, a database or a table. Mapped or marked points in a region of interest can be explored by examining a subregion with higher resolution. The points are analyzed and/or compared by examining, either visually or mathematically, their relative locations, their absolute locations within the region, and/or metrics other than location.

摘要翻译： 描述了对应于目标字符串的数据集的操纵，存储，建模，可视化和量化的方法。 提供了许多目标字符串。 使用迭代算法来生成对应于可以用作迭代函数的域的某些点的比较串。 优选地，这些点位于复合平面中，例如在Mandelbrot集合或Julia集合中和/或附近。 这些比较字符串也是数据集。 通过评估具有比较串和多个目标串中的一个作为输入的功能来对比较串进行评分。 分数测量比较字符串和目标字符串之间的关系。 对于多个其他目标串可以重复评估。 对应于比较字符串的得分或其他属性用于确定目标字符串在地图上的位置。 目标字符串也可以由可视显示器上的点标记。 对应于目标字符串的点的坐标或比较串的属性可以存储在存储器，数据库或表中。 可以通过检查具有更高分辨率的子区域来探索目标区域中的映射或标记点。 通过在视觉上或数学上检查其相对位置，其在该区域内的绝对位置和/或位置以外的度量来分析和/或比较要点。