公开(公告)号：US07105352B2

公开(公告)日：2006-09-12

申请号：US10189107

申请日：2002-07-01

申请人： Sanford A. Asher ,  Vladimir L. Alexeev ,  Igor K. Lednev ,  Anjal C. Sharma ,  Craig Wilcox

发明人： Sanford A. Asher ,  Vladimir L. Alexeev ,  Igor K. Lednev ,  Anjal C. Sharma ,  Craig Wilcox

IPC分类号： G01N33/66 ,  G01N21/31 ,  G01N21/63 ,  A61F2/14

CPC分类号： B01J13/00 ,  B01J13/0065 ,  G01J3/18 ,  G01N21/4788 ,  G01N21/77 ,  G01N31/222 ,  G02B26/002 ,  Y10T436/143333 ,  Y10T436/144444

摘要： The present invention is related to glucose sensors that are capable of detecting the concentration or level of glucose in a solution or fluid having either low or high ionic strength. The glucose sensors of the present invention comprise a polymerized crystalline colloidal array (PCCA) and a molecular recognition component capable of responding to glucose. The molecular recognition component may be a boronic acid, such as a phenylboronic acid, glucose oxidase, a combination of phenylboronic acid and poly(ethylene)glycol or crown ether, or another component capable of detecting glucose in various fluids and solutions. The glucose sensors of the present invention may be useful in the development of noninvasive or minimally invasive in vivo glucose sensors for patients having diabetes mellitus.

公开(公告)号：US20050048541A1

公开(公告)日：2005-03-03

申请号：US10877380

申请日：2004-06-25

申请人： Craig Wilcox ,  Dennis Curran

发明人： Craig Wilcox ,  Dennis Curran

IPC分类号： C07D307/58 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C07D307/58 ,  C07H21/04

摘要： A method of separating compounds, includes: a. tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; b. tagging at least a second organic compound with a second tagging moiety different from the first tagging moiety to result in a second tagged compound, the first tagging moiety and the second tagging moiety including at least one of a common repeat unit, but having a different number of the repeat units therein, the greater the number of repeat units, the greater the polarity of the tagging moiety; and c. separating the first tagged compound from a mixture including at least the second tagged compound using a chromatographic separation technique based upon differences in the number of repeat units between the first tagging moiety and the second tagging moiety. A method of separating compounds includes: a. tagging at least a first organic compound with a first nonfluorous tagging moiety to result in a first tagged compound; b. tagging at least a second organic compound with a second nonfluorous tagging moiety different from the first tagging moiety to result in a second tagged compound, the first nonfluorous tagging moiety and the second nonfluorous tagging moiety including at least one of a common repeat unit, but having a different number of the repeat units therein, the greater the number of repeat units, the greater the affinity of the nonfluorous tagging moiety for a stationary phase of a chromatographic separation technique; and c. separating the first tagged compound from a mixture including at least the second tagged compound using a chromatographic separation technique based upon differences in the number of repeat units between the first nonfluorous tagging moiety and the second nonfluorous tagging moiety.

摘要翻译： 分离化合物的方法包括：a。 标记至少第一有机化合物与第一标记部分以产生第一标记化合物; b。 标记至少第二有机化合物与第二标记部分不同于第一标记部分以产生第二标记化合物，第一标记部分和第二标记部分包括共同重复单元中的至少一个，但具有不同数目 的重复单元，重复单元的数量越多，标记部分的极性越大; 和c。 基于第一标记部分和第二标记部分之间的重复单元数的差异，使用色谱分离技术，从包含至少第二标记化合物的混合物中分离第一标记化合物。 分离化合物的方法包括：a。 标记至少第一有机化合物与第一非氟标记部分以产生第一标记化合物; b。 标记至少第二有机化合物与不同于第一标记部分的第二非氟标记部分以产生第二标记化合物，第一非氟标记部分和第二非氟标记部分包括共同重复单元中的至少一个，但具有 不同数量的重复单元，重复单元的数量越多，非氟标记部分对于色谱分离技术的固定相的亲和力越大; 和c。 基于第一非氟标记部分和第二非氟标签部分之间的重复单元数的差异，使用色谱分离技术从包含至少第二标记化合物的混合物中分离第一标记化合物。