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公开(公告)号：US11578917B2
公开(公告)日：2023-02-14
申请号：US16697217
申请日：2019-11-27
申请人： Sanofi Pasteur SA
摘要： A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer comprising a rotary drum for receiving the frozen particles, and a stationary vacuum chamber housing the rotary drum, wherein for the production of the particles under closed conditions the vacuum chamber is adapted for closed operation during processing of the particles; the drum is in open communication with the vacuum chamber; and at least one transfer section is provided for a product transfer between a separate device of the process line and the freeze-dryer, the freeze-dryer and the transfer section being separately adapted for closed operation, wherein the transfer section comprises a temperature-controllable inner wall surface.
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公开(公告)号：US11499777B2
公开(公告)日：2022-11-15
申请号：US16736832
申请日：2020-01-08
申请人： Sanofi Pasteur SA
发明人： Thomas Gebhard , Roland Kaiser , Bernhard Luy , Matthias Plitzko , Manfred Struschka , Christian Zerillo
摘要： The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamber.
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公开(公告)号：US10451345B2
公开(公告)日：2019-10-22
申请号：US14348880
申请日：2012-10-04
申请人： Sanofi Pasteur SA
摘要： A heating device (124) for heating particles to be freeze-dried in a rotary drum (102) of a freeze-dryer (100) is provided, the device comprising at least one radiation emitter (202) for applying radiation heat to the particles, and a tube-shaped separator (204) for separating the particles from the at least one emitter (202). The separator (202) being integrally closed at one end and separating an emitter volume (206) encompassing the at least one emitter (202) from a drum process volume (126) inside the drum (102), wherein the heating device (124) protrudes into the drum process volume (126) such that said integrally closed end of the separator (204) is arranged inside the drum (102) as a free end.
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公开(公告)号：US20140373383A1
公开(公告)日：2014-12-25
申请号：US14349028
申请日：2012-10-04
申请人： SANOFI PASTEUR SA
摘要： A rotary drum (302) for use within a vacuum chamber (212) in a vacuum freeze-dryer (204) for the bulkware production of freeze-dried particles is provided. The drum (302) is in open communication with the vacuum chamber (212) and comprises a main section (304) terminated by a front plate (306) and a rear plate (308), the rear plate (308) is adapted for connection with a rotary supporting shaft (312) for rotary support of the drum (302), and the rear plate (308) is permeable for sublimation vapor from freeze-drying the particles.
摘要翻译： 提供了一种用于真空冷冻干燥器（204）中真空室（212）内的旋转滚筒（302），用于制造冷冻干燥颗粒的散装件。 鼓（302）与真空室（212）开放连通，并且包括由前板（306）和后板（308）端接的主部分（304），后板（308）适于连接 具有用于滚筒（302）的旋转支撑的旋转支撑轴（312），并且后板（308）对于升华蒸气是可渗透的，以使颗粒冷冻干燥。
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公开(公告)号：US09347707B2
公开(公告)日：2016-05-24
申请号：US14349028
申请日：2012-10-04
申请人： Sanofi Pasteur SA
摘要： A rotary drum (302) for use within a vacuum chamber (212) in a vacuum freeze-dryer (204) for the bulkware production of freeze-dried particles is provided. The drum (302) is in open communication with the vacuum chamber (212) and comprises a main section (304) terminated by a front plate (306) and a rear plate (308), the rear plate (308) is adapted for connection with a rotary supporting shaft (312) for rotary support of the drum (302), and the rear plate (308) is permeable for sublimation vapor from freeze-drying the particles.
摘要翻译： 提供了一种用于真空冷冻干燥器（204）中真空室（212）内的旋转滚筒（302），用于制造冷冻干燥颗粒的散装件。 鼓（302）与真空室（212）开放连通，并且包括由前板（306）和后板（308）端接的主部分（304），后板（308）适于连接 具有用于滚筒（302）的旋转支撑的旋转支撑轴（312），并且后板（308）对于升华蒸气是可渗透的，以使颗粒冷冻干燥。
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公开(公告)号：US20140237846A1
公开(公告)日：2014-08-28
申请号：US14348850
申请日：2012-10-04
申请人： SANOFI PASTEUR SA
IPC分类号： F26B5/06
摘要： A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer (100) for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer (100) comprising a rotary drum (104, 302) for receiving the frozen particles, and a stationary vacuum chamber (102) housing the rotary drum (104, 302), wherein for the production of the particles under closed conditions the vacuum chamber (102) is adapted for closed operation during processing of the particles. The drum (104, 302) is in open communication with the vacuum chamber (102) and at least one transfer section (106, 108) is provided for a product transfer between a separate device of the process line and the freeze-dryer (100), the freeze-dryer (100) and the transfer section (106, 108) being separately adapted for closed operation, wherein the transfer section (106, 108) comprises a temperature-controllable inner wall surface
摘要翻译： 提供了一种用于在封闭条件下生产冷冻干燥颗粒的生产线，所述生产线包括用于在封闭条件下制造冷冻干燥颗粒的冷冻干燥器（100）的冷冻干燥器（100），所述冷冻干燥器（100）包括： 用于接收冷冻颗粒的旋转滚筒（104,302）和容纳旋转滚筒（104,302）的固定真空室（102），其中为了在封闭状态下产生颗粒，真空室（102）适于 在颗粒加工过程中关闭操作。 鼓（104,302）与真空室（102）打开连通，并且提供至少一个传送部分（106,108），用于在处理线的分开的装置与冷冻干燥器（100）之间的产品转移 ），所述冷冻干燥器（100）和所述传送部分（106,108）分别适于闭合操作，其中所述传送部分（106,108）包括温度可控内壁表面
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公开(公告)号：US11512898B2
公开(公告)日：2022-11-29
申请号：US16654012
申请日：2019-10-16
申请人： Sanofi Pasteur SA
摘要： A heating device (124) for heating particles to be freeze-dried in a rotary drum (102) of a freeze-dryer (100) is provided, the device comprising at least one radiation emitter (202) for applying radiation heat to the particles, and a tube-shaped separator (204) for separating the particles from the at least one emitter (202), The separator (202) being integrally closed at one end and separating an emitter volume (206) encompassing the at least one emitter (202) from a drum process volume (126) inside the drum (102), wherein the heating device (124) protrudes into the drum process volume (126) such that said integrally closed end of the separator (204) is arranged inside the drum (102) as a free end.
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公开(公告)号：US10533800B2
公开(公告)日：2020-01-14
申请号：US15328068
申请日：2015-07-20
申请人： Sanofi Pasteur SA
发明人： Thomas Gebhard , Roland Kaiser , Bernhard Luy , Matthias Plitzko , Manfred Struschka , Christian Zerillo
摘要： The present invention provides, inter alia, for a liquid feeding device for the generation of droplets, in particular for the use in a process line for the production of freeze-dried particles, with a droplet ejection section for ejecting liquid droplets in an ejection direction, the droplet ejection section comprising at least one inlet port for receiving a liquid to be ejected, a liquid chamber for retaining the liquid, and a nozzle for ejecting the liquid from the liquid chamber to form droplets, wherein the liquid chamber is restricted by a membrane on one side thereof, the membrane being vibratable by an excitation unit, wherein the longitudinal axis of the liquid chamber is tilted relative to the longitudinal axis of the nozzle, and/or the liquid feeding device further comprises a deflection section for separating the droplets from each other by means of at least one gas jet, wherein the deflection section gas jet intersects perpendicular with an ejection path of the liquid ejected from the liquid chamber.
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公开(公告)号：US10527350B2
公开(公告)日：2020-01-07
申请号：US14348850
申请日：2012-10-04
申请人： Sanofi Pasteur SA
摘要： A process line for the production of freeze-dried particles under closed conditions is provided, the process line comprising a freeze-dryer (100) for the bulkware production of freeze-dried particles under closed conditions, the freeze-dryer (100) comprising a rotary drum (104, 302) for receiving the frozen particles, and a stationary vacuum chamber (102) housing the rotary drum (104, 302), wherein for the production of the particles under closed conditions the vacuum chamber (102) is adapted for closed operation during processing of the particles. The drum (104, 302) is in open communication with the vacuum chamber (102) and at least one transfer section (106, 108) is provided for a product transfer between a separate device of the process line and the freeze-dryer (100), the freeze-dryer (100) and the transfer section (106, 108) being separately adapted for closed operation, wherein the transfer section (106, 108) comprises a temperature-controllable inner wall surface.
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公开(公告)号：US20150007445A1
公开(公告)日：2015-01-08
申请号：US14348880
申请日：2012-10-04
申请人： SANOFI PASTEUR SA
CPC分类号： F26B3/30 , F26B5/06 , F26B11/026
摘要： A heating device (124) for heating particles to be freeze-dried in a rotary drum (102) of a freeze-dryer (100) is provided, the device comprising at least one radiation emitter (202) for applying radiation heat to the particles, and a tube-shaped separator (204) for separating the particles from the at least one emitter (202). The separator (202) being integrally closed at one end and separating an emitter volume (206) encompassing the at least one emitter (202) from a drum process volume (126) inside the drum (102), wherein the heating device (124) protrudes into the drum process volume (126) such that said integrally closed end of the separator (204) is arranged inside the drum (102) as a free end.
摘要翻译： 提供一种加热装置（124），用于在冷冻干燥机（100）的旋转滚筒（102）中加热要冷冻干燥的颗粒，该装置包括至少一个用于向颗粒施加辐射热的辐射发射器（202） ，以及用于从所述至少一个发射器（202）分离所述粒子的管状分离器（204）。 分离器（202）在一端整体封闭，并将包围至少一个发射器（202）的发射体（206）与滚筒（102）内的滚筒加工体积（126）分开，其中加热装置（124） 突出到滚筒加工体积（126）中，使得分离器（204）的所述整体封闭的端部作为自由端布置在滚筒（102）内。
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