公开(公告)号：US20080234495A1

公开(公告)日：2008-09-25

申请号：US11996787

申请日：2006-07-21

申请人： Satyanarayana Chava ,  Seeta Ramanjaneyulu Gorantla ,  Ramdas Chavakula ,  Babu Rao Konudula

发明人： Satyanarayana Chava ,  Seeta Ramanjaneyulu Gorantla ,  Ramdas Chavakula ,  Babu Rao Konudula

IPC分类号： C07D403/12

CPC分类号： C07D209/16

摘要： The present invention encompasses a method for the preparation of Almotriptan and its pharmaceutically acceptable salts comprises, i) Methylation of 3-[5-(1-Pyrrolidinyl sulfonyl methyl) 1H-indol-yl]ethane amine ii) Treating crude Almotriptan with a hydroxy benzoic acid yields hydroxy benzoic acid addition salt of Almotriptan iii) Converting Almotriptan hydroxy benzoic acid addition salt to Almotriptan and iv) Salification of Almotriptan to its pharmaceutically acceptable salts

摘要翻译： 本发明包括制备阿莫曲坦及其药学上可接受的盐的方法，包括：i）3- [5-（1-吡咯烷基磺酰基甲基）1H-吲哚基]乙烷胺的甲基化; ii）用羟基 苯甲酸产生阿莫曲坦的羟基苯甲酸加成盐iii）将阿莫曲坦羟基苯甲酸加成盐转化为阿莫曲坦，和iv）将阿莫托他汀盐化至其药学上可接受的盐

公开(公告)号：US07943784B2

公开(公告)日：2011-05-17

申请号：US11996787

申请日：2006-07-21

申请人： Satyanarayana Chava ,  Seeta Ramanjaneyulu Gorantla ,  Ramdas Chavakula ,  Babu Rao Konudula

发明人： Satyanarayana Chava ,  Seeta Ramanjaneyulu Gorantla ,  Ramdas Chavakula ,  Babu Rao Konudula

IPC分类号： C07D403/12

CPC分类号： C07D209/16

摘要： The present invention encompasses a method for the preparation of Almotriptan and its pharmaceutically acceptable salts comprises, i) Methylation of 3-[5-(1-Pyrrolidinyl sulfonyl methyl)1H-indol-yl]ethane amine ii) Treating crude Almotriptan with a hydroxy benzoic acid yields hydroxy benzoic acid addition salt of Almotriptan iii) Converting Almotriptan hydroxy benzoic acid addition salt to Almotriptan and iv) Salification of Almotriptan to its pharmaceutically acceptable salts.

摘要翻译： 本发明包括制备阿莫曲坦及其药学上可接受的盐的方法，包括：i）3- [5-（1-吡咯烷基磺酰基甲基）1H-吲哚基]乙烷胺的甲基化; ii）用羟基 苯甲酸产生阿莫曲坦的羟基苯甲酸加成盐iii）将阿莫曲坦羟基苯甲酸加成盐转化为阿莫曲坦，和iv）将阿莫曲坦盐化为其药学上可接受的盐。

公开(公告)号：US20110144383A1

公开(公告)日：2011-06-16

申请号：US12918046

申请日：2009-02-18

申请人： Ataharoddin Khala ,  Venkata Srinivas Rao Potla ,  Govind Singh Rawat ,  Babu Rao Konudula ,  Yogendra Kumar Chauhan ,  Debashish Datta

发明人： Ataharoddin Khala ,  Venkata Srinivas Rao Potla ,  Govind Singh Rawat ,  Babu Rao Konudula ,  Yogendra Kumar Chauhan ,  Debashish Datta

IPC分类号： C07C227/34

CPC分类号： C07C227/34 ,  C07C229/08

摘要： Disclosed herein is a process for the preparing (S)-3-(aminomethyl)-5-methylhexanoic acid by optical resolution of (±)-3-(aminomethyl)-5-methylhexanoic acid and a resolving agent employing a suitable solvent.

摘要翻译： 本文公开了通过（±）-3-（氨基甲基）-5-甲基己酸的光学拆分和使用合适溶剂的拆分剂制备（S）-3-（氨基甲基）-5-甲基己酸的方法。