公开(公告)号：US20040102451A1

公开(公告)日：2004-05-27

申请号：US10654157

申请日：2003-09-03

申请人： Schering Corporation and Pharmacopeia, Inc.

发明人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer ,  Ronald J. Doll ,  Viyyoor M. Girijavallabhan ,  Lawrence W. Dillard ,  Vinh D. Tran ,  Zhen Min He ,  Ray Anthony James ,  Haengsoon Park

IPC分类号： A61K031/519 ,  C07D487/02

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolonull1,5-anullpyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。

公开(公告)号：US20040209878A1

公开(公告)日：2004-10-21

申请号：US10776988

申请日：2004-02-11

申请人： Schering Corporation and Pharmacopeia, Inc.

发明人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer ,  Ronald J. Doll ,  Viyyoor M. Girijavallabhan ,  Alan Mallams ,  Carmen S. Alvarez ,  Kartik M. Keertikar ,  Jocelyn Rivera ,  Tin-Yau Chan ,  Vincent Madison ,  Thierry O. Fischmann ,  Lawrence W. Dillard ,  Vinh D. Tran ,  Zhen Min He ,  Ray Anthony James ,  Haengsoon Park ,  Vidyadhar M. Paradkar ,  Douglas Walsh Hobbs

IPC分类号： A61K031/5377 ,  A61K031/519 ,  C07D487/04

CPC分类号： C07D487/04 ,  A61K31/495

摘要： In its many embodiments, the present invention provides a novel class of pyrazolonull1,5-anullpyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

公开(公告)号：US20040102452A1

公开(公告)日：2004-05-27

申请号：US10654163

申请日：2003-09-03

申请人： Schering Corporation and Pharmacopeia, Inc.

发明人： Timothy J. Guzi ,  Kamil Paruch ,  Michael P. Dwyer ,  Ronald J. Doll ,  Viyyoor M. Girijavallabhan ,  Chad Knutson ,  Brian McKittrick ,  Lawrence W. Dillard ,  Vinh D. Tran ,  Zhen Min He ,  Ray Anthony James ,  Haengsoon Park

IPC分类号： A61K031/519 ,  C07D487/02

CPC分类号： C07D487/04

摘要： In its many embodiments, the present invention provides a novel class of pyrazolonull1,5-anullpyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.