公开(公告)号：US20160158377A1

公开(公告)日：2016-06-09

申请号：US14963510

申请日：2015-12-09

申请人： Scott L. Ackler ,  Nathan B. Bennett ,  Erwin R. Boghaert ,  Steve C. Cullen ,  George Doherty ,  Robin R. Frey ,  Anthony R. Haight ,  Andrew S. Judd ,  Aaron R. Kunzer ,  Xiaoqiang Shen ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Xilu Wang ,  Dennie S. Welch ,  Michael D. Wendt

发明人： Scott L. Ackler ,  Nathan B. Bennett ,  Erwin R. Boghaert ,  Steve C. Cullen ,  George Doherty ,  Robin R. Frey ,  Anthony R. Haight ,  Andrew S. Judd ,  Aaron R. Kunzer ,  Xiaoqiang Shen ,  Xiaohong Song ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Zhi-Fu Tao ,  Xilu Wang ,  Dennie S. Welch ,  Michael D. Wendt

IPC分类号： A61K47/48 ,  C07K16/18 ,  C07D513/04 ,  C07D417/14 ,  C07D487/04

CPC分类号： C07K16/18 ,  A61K47/6803 ,  C07D417/14 ,  C07D487/04 ,  C07D513/04 ,  C07K2317/73

摘要： Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.

摘要翻译： 本文公开了包含小分子Bcl-xL抑制剂的小分子Bcl-xL抑制剂和抗体药物偶联物（ADC）。 本公开的Bcl-xL抑制剂和ADC尤其可用于抑制抗凋亡Bcl-xL蛋白作为治疗涉及失调性凋亡途径的疾病的治疗方法。

公开(公告)号：US10760873B2

公开(公告)日：2020-09-01

申请号：US15858162

申请日：2017-12-29

申请人： Wei Sun ,  Yecheng Wu ,  Xiaoqiang Shen ,  Guohua Jin ,  Dingfu Tang ,  Ye Sun ,  Xiaoping Ji

发明人： Wei Sun ,  Yecheng Wu ,  Xiaoqiang Shen ,  Guohua Jin ,  Dingfu Tang ,  Ye Sun ,  Xiaoping Ji

IPC分类号： F41B11/647

摘要： The present disclosure relates to the field of air rifles, and particularly to a gear-type air rifle gear cock structure, including a air cylinder, a gear cock controller, a rack, and a rack reset spring, the gear cock controller is fixedly connected with the air cylinder, and the rack is arranged between the air cylinder and the gear cock controller; the air cylinder includes a air cylinder body, a piston, and a magazine, the air cylinder body has a hollow structure with an air chamber inside, the piston is arranged in the air chamber inside the air cylinder body, the magazine communicates with the air chamber through an outlet pipe; two ends of the rack are a piston fixing end and a spring fixing end respectively, the piston fixing end is connected with the piston through a lug arranged at the piston fixing end, the spring fixing end is connected with the rack reset spring, two ends of the rack reset spring are respectively fixed on the rack and the air cylinder.