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公开(公告)号：US08748175B2
公开(公告)日：2014-06-10
申请号：US13499155
申请日：2009-11-02
申请人： Se-Ho Kim , Ki Hwan Chang , Kwang-Won Hong , Yong-Won Shin , Min-soo Kim , Hae-Won Lee , Yong Nam Shin , Kyung Hwan Ryoo , Dong Hyuck Seo , Jong-Hwa Won , Min-Kyu Hur
发明人： Se-Ho Kim , Ki Hwan Chang , Kwang-Won Hong , Yong-Won Shin , Min-soo Kim , Hae-Won Lee , Yong Nam Shin , Kyung Hwan Ryoo , Dong Hyuck Seo , Jong-Hwa Won , Min-Kyu Hur
CPC分类号： C07K16/2863 , C07K2317/565
摘要： Provided are antibodies specifically binding to the epidermal growth factor receptor (EGFR) which are effective for the treatment of EGFR-mediated cancers.
摘要翻译： 提供了与EGFR介导的癌症治疗有效的表皮生长因子受体（EGFR）特异性结合的抗体。
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公开(公告)号：US20120231021A1
公开(公告)日：2012-09-13
申请号：US13499155
申请日：2009-11-02
申请人： Se-Ho Kim , Ki Hwan Chang , Kwang-Won Hong , Yong-Won Shin , Min-soo Kim , Hae-Won Lee , Yong Nam Shin , Kyung Hwan Ryoo , Dong Hyuck Seo
发明人： Se-Ho Kim , Ki Hwan Chang , Kwang-Won Hong , Yong-Won Shin , Min-soo Kim , Hae-Won Lee , Yong Nam Shin , Kyung Hwan Ryoo , Dong Hyuck Seo
CPC分类号： C07K16/2863 , C07K2317/565
摘要： Provided are antibodies specifically binding to the epidermal growth factor receptor (EGFR) which are effective for the treatment of EGFR-mediated cancers.
摘要翻译： 提供了与EGFR介导的癌症治疗有效的表皮生长因子受体（EGFR）特异性结合的抗体。
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3.发明授权Human antibodies specifically binding to the hepatitis B virus surface antigen 有权人抗体特异性结合乙型肝炎病毒表面抗原公开(公告)号：US08840895B2
公开(公告)日：2014-09-23
申请号：US13518683
申请日：2010-07-08
申请人： Se-Ho Kim , Ki Hwan Chang , Kwang-Won Hong , Yong-Won Shin , Min-soo Kim , Hae-Won Lee , Kyung Hwan Ryoo , Dong Hyuck Seo , Jean Man Kim , Yong Nam Shin , Sunmi Koo , Jung-Ae Lim , Mijung Lee , Yeon Kyung Lee , Misun Seo
发明人： Se-Ho Kim , Ki Hwan Chang , Kwang-Won Hong , Yong-Won Shin , Min-soo Kim , Hae-Won Lee , Kyung Hwan Ryoo , Dong Hyuck Seo , Jean Man Kim , Yong Nam Shin , Sunmi Koo , Jung-Ae Lim , Mijung Lee , Yeon Kyung Lee , Misun Seo
CPC分类号： C07K16/082 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/92
摘要： Provided are antibodies specifically binding to the HBV surface antigen (HBsAg) which are effective for the prevention or treatment of hepatitis B.
摘要翻译： 提供了特异性结合HBV表面抗原（HBsAg）的抗体，其有效预防或治疗乙型肝炎。
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4.发明申请HUMAN ANTIBODIES SPECIFICALLY BINDING TO THE HEPATITIS B VIRUS SURFACE ANTIGEN 有权人类抗体特异性结合乙型肝炎病毒表面抗原公开(公告)号：US20120264921A1
公开(公告)日：2012-10-18
申请号：US13518683
申请日：2010-07-08
申请人： Se-Ho Kim , Ki Hwan Chang , Kwang-Won Hong , Yong-Won Shin , Min-soo Kim , Hae-Won Lee , Kyung Hwan Ryoo , Dong Hyuck Seo , Jean Man Kim , Yong Nam Shin , Sunmi Koo , Jung-Ae Lim , Mijung Lee , Yeon Kyung Lee , Misun Seo
发明人： Se-Ho Kim , Ki Hwan Chang , Kwang-Won Hong , Yong-Won Shin , Min-soo Kim , Hae-Won Lee , Kyung Hwan Ryoo , Dong Hyuck Seo , Jean Man Kim , Yong Nam Shin , Sunmi Koo , Jung-Ae Lim , Mijung Lee , Yeon Kyung Lee , Misun Seo
CPC分类号： C07K16/082 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/565 , C07K2317/92
摘要： Provided are antibodies specifically binding to the HBV surface antigen (HBsAg) which are effective for the prevention or treatment of hepatitis B.
摘要翻译： 提供了特异性结合HBV表面抗原（HBsAg）的抗体，其有效预防或治疗乙型肝炎。
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5.发明授权Pharmaceutical preparation of recombinant factor VIII lyophilized without albumin as a stabilizer 有权重组因子VIII的药物制剂冻干，无白蛋白作为稳定剂公开(公告)号：US06887852B1
公开(公告)日：2005-05-03
申请号：US10912167
申请日：2004-08-06
申请人： Sang Hoon Paik , Yong Nam Shin , Jean Man Kim , Jae Wook Huh , Jung Sik Lee , Ki Sung Kwon , Ji Hyun Chun
发明人： Sang Hoon Paik , Yong Nam Shin , Jean Man Kim , Jae Wook Huh , Jung Sik Lee , Ki Sung Kwon , Ji Hyun Chun
IPC分类号： A61K38/16 , A61K9/19 , A61K38/37 , A61K47/18 , C07K14/755 , A61K38/00 , A61K35/14 , C12P21/02
CPC分类号： A61K9/19 , A61K38/37 , A61K47/183 , C07K14/755
摘要： Disclosed is a lyophilized preparation of recombinant factor VIII used as a therapeutic preparation of hemophilia A. The lyophilized preparation of recombinant factor VIII is prepared by performing lyophilization using a mixture comprising 6 to 100 mM of L-arginine, 3.5 to 50 mM of L-isoleucine, and 10 to 100 mM of L-glutamic acid as a stabilizer for stabilizing the recombinant factor VIII which exhibits an unstable activity during lyophilization, rather than using human blood derived albumin.
摘要翻译： 公开了用作血友病A的治疗制剂的重组因子VIII的冻干制剂。重组因子VIII的冻干制剂通过使用包含6至100mM L-精氨酸，3.5至50mM L- 异亮氨酸和10至100mM的L-谷氨酸作为稳定重组因子VIII的稳定剂，其在冻干期间表现出不稳定的活性，而不是使用人血清白蛋白。
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