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公开(公告)号：US12071480B2
公开(公告)日：2024-08-27
申请号：US17505911
申请日：2021-10-20
申请人： Seagen Inc.
发明人： Shyra Gardai , Matthew Levengood , Vivian Trang , Lori Westendorf , Christopher Carosino , Che Leung-Law , Michael Feldhaus
CPC分类号： C07K16/2803 , A61P35/00 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2319/50 , C07K2319/73
摘要： Humanized antibodies, including masked antibodies that specifically bind to CD47 are provided. Methods for using anti-CD47 antibodies, including masked antibodies, to modulate activity of (e.g., inhibit proliferation of) a CD47-expressing cell, as well as for the treatment of one or more diseases or disorders (e.g., cancer) associated with CD47-expressing cells, are provided.
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公开(公告)号：US20220135674A1
公开(公告)日：2022-05-05
申请号：US17505911
申请日：2021-10-20
申请人： Seagen Inc.
发明人： Shyra Gardai , Matthew Levengood , Vivian Trang , Lori Westendorf , Christopher Carosino , Che Leung-Law , Michael Feldhaus
摘要： Humanized antibodies, including masked antibodies that specifically bind to CD47 are provided. Methods for using anti-CD47 antibodies, including masked antibodies, to modulate activity of (e.g., inhibit proliferation of) a CD47-expressing cell, as well as for the treatment of one or more diseases or disorders (e.g., cancer) associated with CD47-expressing cells, are provided.
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公开(公告)号：US11180552B2
公开(公告)日：2021-11-23
申请号：US16203809
申请日：2018-11-29
申请人： Seagen Inc.
发明人： Shyra Gardai , Matthew Levengood , Vivian Trang , Lori Westendorf , Christopher Carosino , Che Leung-Law , Michael Feldhaus
摘要： Humanized antibodies, including masked antibodies that specifically bind to CD47 are provided. Methods for using anti-CD47 antibodies, including masked antibodies, to modulate activity of (e.g., inhibit proliferation of) a CD47-expressing cell, as well as for the treatment of one or more diseases or disorders (e.g., cancer) associated with CD47-expressing cells, are provided.
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