公开(公告)号：US20230330241A1

公开(公告)日：2023-10-19

申请号：US18171208

申请日：2023-02-17

申请人： Seagen Inc.

发明人： Emily STEVENS ,  Hong LI ,  William HANLEY ,  Phillip GARFIN ,  Shawna HENGEL

IPC分类号： A61K47/68 ,  A61P35/00 ,  A61K9/00 ,  C07K16/28

CPC分类号： A61K47/6801 ,  A61P35/00 ,  A61K9/0019 ,  C07K16/2818 ,  C07K16/2827

摘要： Methods for using anti-LIV1 antibodies and antibody-drug conjugates, including anti-LIV1 antibody-drug conjugates, to inhibit proliferation of a cell, such as a LIV1-expressing cell, as well as for the treatment of cancers, such as, e.g., LIV1-associated solid tumors and breast cancer (e.g., locally advanced or metastatic breast cancer), are provided.

公开(公告)号：US20210030885A1

公开(公告)日：2021-02-04

申请号：US16934745

申请日：2020-07-21

申请人： Seagen Inc.

发明人： Emily STEVENS ,  Hong LI ,  William HANLEY ,  Phillip GARFIN ,  Shawna HENGEL

IPC分类号： A61K47/68 ,  A61P35/00 ,  C07K16/28 ,  A61K9/00

摘要： Methods for using anti-LIV1 antibodies and antibody-drug conjugates, including anti-LIV1 antibody-drug conjugates, to inhibit proliferation of a cell, such as a LIV1-expressing cell, as well as for the treatment of cancers, such as, e.g., LIV1-associated solid tumors and breast cancer (e.g., locally advanced or metastatic breast cancer), are provided.