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公开(公告)号:US09290491B2
公开(公告)日:2016-03-22
申请号:US14333003
申请日:2014-07-16
IPC分类号: C07D221/02 , C07D451/02 , A61K31/46 , A61K31/485 , A61K45/06
CPC分类号: A61K31/46 , A61K31/485 , A61K45/06 , C07D451/02
摘要: The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.
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公开(公告)号:US08247555B2
公开(公告)日:2012-08-21
申请号:US13081162
申请日:2011-04-06
IPC分类号: C07D221/02
CPC分类号: A61K31/46 , A61K31/485 , A61K45/06 , C07D451/02
摘要: The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.
摘要翻译: 本发明提供3-内 - (8- {2- [环己基甲基 - ((S)-2,3-二羟基 - 丙酰基)氨基]乙基} -8-氮杂 - 双环[3.2.1]辛烷的结晶硫酸盐 -3-基)苯甲酰胺或其溶剂合物。 本发明还提供包含这种结晶盐形式的药物组合物,使用这种结晶盐形式治疗与阿片样物质受体活性相关的疾病的方法,以及可用于制备此类结晶盐形式的方法。
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3.
公开(公告)号:US20150073014A1
公开(公告)日:2015-03-12
申请号:US14333003
申请日:2014-07-16
IPC分类号: C07D451/02
CPC分类号: A61K31/46 , A61K31/485 , A61K45/06 , C07D451/02
摘要: The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.
摘要翻译: 本发明提供3-内 - (8- {2- [环己基甲基 - ((S)-2,3-二羟基 - 丙酰基)氨基]乙基} -8-氮杂 - 双环[3.2.1]辛烷的结晶硫酸盐 -3-基)苯甲酰胺或其溶剂合物。 本发明还提供包含这种结晶盐形式的药物组合物,使用这种结晶盐形式治疗与阿片样物质受体活性相关的疾病的方法,以及可用于制备此类结晶盐形式的方法。
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公开(公告)号:US08536335B2
公开(公告)日:2013-09-17
申请号:US13550781
申请日:2012-07-17
IPC分类号: C07D221/02
CPC分类号: A61K31/46 , A61K31/485 , A61K45/06 , C07D451/02
摘要: The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.
摘要翻译: 本发明提供3-内 - (8- {2- [环己基甲基 - ((S)-2,3-二羟基 - 丙酰基)氨基]乙基} -8-氮杂 - 双环[3.2.1]辛烷的结晶硫酸盐 -3-基)苯甲酰胺或其溶剂合物。 本发明还提供包含这种结晶盐形式的药物组合物,使用这种结晶盐形式治疗与阿片样物质受体活性相关的疾病的方法,以及可用于制备此类结晶盐形式的方法。
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公开(公告)号:US20110184008A1
公开(公告)日:2011-07-28
申请号:US13081162
申请日:2011-04-06
IPC分类号: A61K31/46 , A61P1/00 , A61K31/485 , A61P25/04
CPC分类号: A61K31/46 , A61K31/485 , A61K45/06 , C07D451/02
摘要: The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.
摘要翻译: 本发明提供3-内 - (8- {2- [环己基甲基 - ((S)-2,3-二羟基 - 丙酰基)氨基]乙基} -8-氮杂 - 双环[3.2.1]辛烷的结晶硫酸盐 -3-基)苯甲酰胺或其溶剂合物。 本发明还提供包含这种结晶盐形式的药物组合物,使用这种结晶盐形式治疗与阿片样物质受体活性相关的疾病的方法,以及可用于制备此类结晶盐形式的方法。
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公开(公告)号:US07943772B2
公开(公告)日:2011-05-17
申请号:US12072534
申请日:2008-02-27
IPC分类号: C07D221/02
CPC分类号: A61K31/46 , A61K31/485 , A61K45/06 , C07D451/02
摘要: The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamideor a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.
摘要翻译: 本发明提供3-内 - (8- {2- [环己基甲基 - ((S)-2,3-二羟基 - 丙酰基)氨基]乙基} -8-氮杂 - 双环[3.2.1]辛烷的结晶硫酸盐 -3-基)苯甲酰胺或其溶剂合物。 本发明还提供包含这种结晶盐形式的药物组合物,使用这种结晶盐形式治疗与阿片样物质受体活性相关的疾病的方法,以及可用于制备此类结晶盐形式的方法。
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公开(公告)号:US08816091B2
公开(公告)日:2014-08-26
申请号:US13965691
申请日:2013-08-13
IPC分类号: C07D221/02 , A61K45/06 , A61K31/485 , C07D451/02 , A61K31/46
CPC分类号: A61K31/46 , A61K31/485 , A61K45/06 , C07D451/02
摘要: The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.
摘要翻译: 本发明提供3-内 - (8- {2- [环己基甲基 - ((S)-2,3-二羟基 - 丙酰基)氨基]乙基} -8-氮杂 - 双环[3.2.1]辛烷的结晶硫酸盐 -3-基)苯甲酰胺或其溶剂合物。 本发明还提供包含这种结晶盐形式的药物组合物,使用这种结晶盐形式治疗与阿片样物质受体活性相关的疾病的方法,以及可用于制备此类结晶盐形式的方法。
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公开(公告)号:US20140080856A1
公开(公告)日:2014-03-20
申请号:US13965691
申请日:2013-08-13
IPC分类号: C07D451/02 , A61K45/06 , A61K31/46
CPC分类号: A61K31/46 , A61K31/485 , A61K45/06 , C07D451/02
摘要: The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.
摘要翻译: 本发明提供3-内 - (8- {2- [环己基甲基 - ((S)-2,3-二羟基 - 丙酰基)氨基]乙基} -8-氮杂 - 双环[3.2.1]辛烷的结晶硫酸盐 -3-基)苯甲酰胺或其溶剂合物。 本发明还提供包含这种结晶盐形式的药物组合物,使用这种结晶盐形式治疗与阿片样物质受体活性有关的疾病的方法,以及可用于制备此类结晶盐形式的方法。
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公开(公告)号:US20080207676A1
公开(公告)日:2008-08-28
申请号:US12072534
申请日:2008-02-27
IPC分类号: A61K31/439 , C07D221/22
CPC分类号: A61K31/46 , A61K31/485 , A61K45/06 , C07D451/02
摘要: The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.
摘要翻译: 本发明提供3-内 - (8- {2- [环己基甲基 - ((S)-2,3-二羟基 - 丙酰基)氨基]乙基} -8-氮杂 - 双环[3.2.1]辛烷的结晶硫酸盐 -3-基)苯甲酰胺或其溶剂合物。 本发明还提供包含这种结晶盐形式的药物组合物,使用这种结晶盐形式治疗与阿片样物质受体活性相关的疾病的方法,以及可用于制备此类结晶盐形式的方法。
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