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1.发明公开公开(公告)号：US20230303705A1
公开(公告)日：2023-09-28
申请号：US17917113
申请日：2021-04-09
申请人： Seattle Children's Hospital (dba Seattle Children's Research Institute) , Provincial Health Services Authority , University of Pittsburgh - of the Commonwealth System of Higher Education
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , C07K2319/02 , C07K2319/03
摘要： Some embodiments provided herein also include methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, antibody domain, CAR, cell engager, and/or ADC) to an IL1RAP polypeptide. For example, binders (e.g., antibodies, antigen binding fragments, antibody domains, CARs, cell engagers, and/or ADCs) that bind to an IL1RAP polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having cancer are provided. Some embodiments of the methods and compositions provided herein include chimeric antigen receptors (CARs) which specifically bind to interleukin-1 receptor accessory protein (IL1RAP). Some embodiments include nucleic acids encoding such CARs, and cells containing such CARs. Some embodiments include the use of such CARs in safe and effective therapies for a cancer, such as an IL1RAP-expressing cancer, such as a Ewing's sarcoma and acute myeloid leukemia (AML).
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2.发明公开公开(公告)号：US20240026012A1
公开(公告)日：2024-01-25
申请号：US18027305
申请日：2021-10-08
申请人： Seattle Children's Hospital (dba Seattle Children's Research Institute , University of Pittsburgh - Of the Commonwealth System of Higher Education
CPC分类号： C07K16/2863 , C12N15/86 , A61K39/4631 , C12N5/0634 , A61K35/17 , A61K2239/21 , A61K2239/22 , C12N2510/00
摘要： Some embodiments of the methods and compositions provided herein include methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, antibody domain, CAR, cell engager, and/or ADC) to an FGFR4 polypeptide. For example, binders (e.g., antibodies, antigen binding fragments, antibody domains, CARs, cell engagers, and/or ADCs) acidic box that bind to an FGFR4 polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having cancer are provided. Some embodiments of the methods and compositions provided herein include chimeric antigen receptors (CARs) which specifically bind to fibroblast growth factor receptor 4 (FGFR4). Some embodiments include nucleic acids encoding such CARs, and cells containing such CARs. Some embodiments include the use of such CARs in safe and effective therapies for a cancer, such as an FGFR4-expressing cancer, such as a rhabdomyosarcoma.
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公开(公告)号：US20240166760A1
公开(公告)日：2024-05-23
申请号：US18281157
申请日：2022-03-08
IPC分类号： C07K16/30 , A61K39/00 , A61K39/395 , A61K47/68 , A61P35/00 , C07K14/725 , C07K16/28 , C12N5/0783
CPC分类号： C07K16/3007 , A61K39/3955 , A61K39/4631 , A61K39/464482 , A61K47/68031 , A61K47/68033 , A61K47/68035 , A61K47/6853 , A61P35/00 , C07K14/7051 , C07K16/2803 , C07K16/2809 , C07K16/283 , C07K16/2851 , C12N5/0636 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C07K2319/30
摘要： This document provides methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, antibody domain, CAR, cell engager, and/or ADC) to a CD66e polypeptide. For example, binders (e.g., antibodies, antigen binding fragments, antibody domains, CARs, cell engagers, and/or ADCs) that bind to a CD66e polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having cancer are provided.
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公开(公告)号：US10822379B1
公开(公告)日：2020-11-03
申请号：US15931939
申请日：2020-05-14
发明人： Dimiter Stanchev Dimitrov , Chuan Chen , Dontcho V. Jelev , John W. Mellors , Wei Li , Zehua Sun
IPC分类号： A61K39/395 , A61K39/42 , A61K39/15 , C07K14/165
摘要： This document provides methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, and/or antibody domain) to a SARS-CoV-2 antigen. For example, binders (e.g., antibodies, antigen binding fragments, and antibody domains) that bind to a SARS-CoV-2 polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having COVID-19 (or a viral infection caused by SARS-CoV-2) are provided.
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公开(公告)号：US20240358762A1
公开(公告)日：2024-10-31
申请号：US18685711
申请日：2022-11-03
申请人： UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , The Hospital for Sick Children
发明人： Dimiter Stanchev Dimitrov , Chuan Chen , Wei Li , Zehua Sun , Michael D. Taylor , Abhirami Visvanathan , Olivier Saulnier
CPC分类号： A61K35/17 , A61K39/4611 , A61K39/4613 , A61K39/4631 , A61K39/464411 , A61K47/6849 , A61P35/00 , C07K16/2803 , A61K2239/13 , A61K2239/17 , A61K2239/21 , C07K2317/56
摘要： This document provides methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, antibody domain, CAR, cell engager, and/or ADC) to a PRTG polypeptide. For example, binders (e.g., antibodies, antigen binding fragments, antibody domains, CARs, cell engagers, and/or ADCs) that bind to a PRTG polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having cancer are provided.
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公开(公告)号：US20240034807A1
公开(公告)日：2024-02-01
申请号：US18265125
申请日：2022-02-15
IPC分类号： C07K16/30 , C07K14/725 , C07K16/28
CPC分类号： C07K16/30 , C07K14/7051 , C07K16/2809 , C07K16/283 , C07K16/2803 , C07K2319/30 , C07K2319/03 , C07K2317/622 , C07K2319/02 , C07K2317/31
摘要： This document provides methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, antibody domain, CAR, cell engager, and/or ADC) to a mesothelin polypeptide. For example, binders (e.g., antibodies, antigen binding fragments, antibody domains, CARs, cell engagers, and/or ADCs) that bind to a mesothelin polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having cancer are provided.
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