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公开(公告)号：US09539206B2
公开(公告)日：2017-01-10
申请号：US14238619
申请日：2012-07-09
CPC分类号： A61K9/0056 , A61K9/006 , A61K9/2095 , A61K9/7007 , A61K47/38
摘要： Method for producing and monitoring oral active ingredient films with a base to which a solution containing at least one active ingredient is applied, the method comprising the steps: • metering and mixing the base formulation, • coating the base formulation onto a substrate, so that a strip results • if necessary, drying the base formulation strip coated on the substrate • printing a colorant solution containing at least one active ingredient onto the upper side of the base formulation strip according to the flexographic printing method, • drying the base formulation strip coated on the substrate together with the printed active ingredient solution, • penetrating the base formulation strip coated on the substrate together with the printed active ingredient solution from the upper and/or lower side by means of radiation from a radiation source, • measuring the transmission of the penetrating radiation by means of at least one reception unit on the opposite side of the base formulation strip coated on the substrate together with the printed active ingredient solution.
摘要翻译： 用于制备和监测含有至少一种活性成分的溶液的基质的口服活性成分膜的方法，所述方法包括以下步骤：·计量和混合所述基础制剂，·将所述基础制剂涂布在基材上，使得 条带结果•如果需要，干燥涂覆在基材上的基础制剂条带•根据柔性版印刷方法将含有至少一种活性成分的着色剂溶液印刷到基底制剂条的上侧上;•将涂布的基础制剂条 与印刷的活性成分溶液一起在基底上;·通过来自辐射源的辐射，从上和/或下侧将印刷的活性成分溶液与印刷的活性成分溶液一起穿透基底制剂条;·测量 穿透辐射借助于在该相对侧的至少一个接收单元 e制剂条带与印刷的活性成分溶液一起涂覆在基材上。
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2.发明申请ORODISPERSIBLE FILMS FOR THE MANUFACTURING OF INDIVIDUALISED MEDICINE OR FOR LARGE SCALE PRODUCTION 审中-公开用于制造个体化药物或大规模生产的可以使用的膜公开(公告)号：US20140186427A1
公开(公告)日：2014-07-03
申请号：US14238381
申请日：2012-08-13
CPC分类号： A61K9/006 , A61K9/0056 , A61K9/7007 , A61K9/7084 , A61K31/4985
摘要： The present invention pertains to oral applicable therapeutic dosage forms, in particular to orodispersible films. The present invention especially is directed to orodispersible films comprising a base layer substantially free of therapeutically active agents and a top layer comprising the desired therapeutically active agents. The present invention also concerns suitable base layers for such orodispersible films as well as therapeutical uses thereof and methods for manufacturing them.
摘要翻译： 本发明涉及口服适用的治疗剂型，特别是涉及可分散的膜。 本发明特别涉及包含基本上不含治疗活性剂的基础层和包含所需治疗活性剂的顶层的可分散膜。 本发明还涉及用于这种可分散膜的合适的基底层以及其治疗用途及其制造方法。
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公开(公告)号：US20140272099A1
公开(公告)日：2014-09-18
申请号：US14238619
申请日：2012-07-09
CPC分类号： A61K9/0056 , A61K9/006 , A61K9/2095 , A61K9/7007 , A61K47/38
摘要： Method for producing and monitoring oral active ingredient films with a base to which a solution containing at least one active ingredient is applied, the method comprising the steps: • metering and mixing the base formulation, • coating the base formulation onto a substrate, so that a strip results • if necessary, drying the base formulation strip coated on the substrate • printing a colorant solution containing at least one active ingredient onto the upper side of the base formulation strip according to the flexographic printing method, • drying the base formulation strip coated on the substrate together with the printed active ingredient solution, • penetrating the base formulation strip coated on the substrate together with the printed active ingredient solution from the upper and/or lower side by means of radiation from a radiation source, • measuring the transmission of the penetrating radiation by means of at least one reception unit on the opposite side of the base formulation strip coated on the substrate together with the printed active ingredient solution.
摘要翻译： 用于制备和监测含有至少一种活性成分的溶液的基质的口服活性成分膜的方法，所述方法包括以下步骤：·计量和混合所述基础制剂，·将所述基础制剂涂布在基材上，使得 条带结果•如果需要，干燥涂覆在基材上的基础制剂条带•根据柔性版印刷方法将含有至少一种活性成分的着色剂溶液印刷到基底制剂条的上侧上;•将涂布的基础制剂条 与印刷的活性成分溶液一起在基底上;·通过来自辐射源的辐射，从上和/或下侧将印刷的活性成分溶液与印刷的活性成分溶液一起穿透基底制剂条;·测量 穿透辐射借助于在该相对侧的至少一个接收单元 e制剂条带与印刷的活性成分溶液一起涂覆在基材上。
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公开(公告)号：US20120265158A1
公开(公告)日：2012-10-18
申请号：US13394204
申请日：2010-09-09
CPC分类号： A61K9/7023 , A61K9/7061 , A61K9/7084 , A61K9/7092 , A61K31/135 , A61K47/10 , A61K47/14
摘要： A method for preparing a transdermal patch comprising a substrate layer is provided, the method comprising the steps of contacting an active pharmaceutical ingredient with a retaining means to provide a composition, applying the composition obtained in step (a) to a carrier material to form a substrate layer of the transdermal patch, wherein the retaining means remain within the final transdermal patch.
摘要翻译： 提供了一种制备包含基底层的透皮贴剂的方法，所述方法包括以下步骤：使活性药物成分与保留装置接触以提供组合物，将步骤（a）中获得的组合物应用于载体材料，以形成 透皮贴片的底层，其中保留装置保留在最终透皮贴剂内。
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公开(公告)号：US08440222B2
公开(公告)日：2013-05-14
申请号：US12651167
申请日：2009-12-31
申请人： Heike Hausner , Sebastian Braun , Heiko Spilgies
发明人： Heike Hausner , Sebastian Braun , Heiko Spilgies
CPC分类号： A61K9/7084 , A61L15/585
摘要： A dermal or transdermal therapeutic system comprising a reservoir that contains at least one active substance, an active substance-permeable membrane which delimits the active-substance reservoir, and a closing layer. The closing layer is impermeable to the active substance at a temperature lying below the skin temperature while being permeable at skin temperature and above.
摘要翻译： 皮肤或透皮治疗系统，其包含含有至少一种活性物质的储存器，限定活性物质储存器的活性物质可渗透膜和封闭层。 闭合层在低于皮肤温度的温度下对于活性物质是不透水的，同时在皮肤温度及以上可渗透。
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