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    SMALL PEPTIDIC AND PEPTIDO-MIMETIC AFFINITY LIGANDS FOR FACTOR VIII AND FACTOR VIII-LIKE PROTEINS
    1.
    发明申请
    SMALL PEPTIDIC AND PEPTIDO-MIMETIC AFFINITY LIGANDS FOR FACTOR VIII AND FACTOR VIII-LIKE PROTEINS 审中-公开
    用于因子VIII和因子VIII样蛋白的小肽和肽 - 亲和力配体

    公开(公告)号：US20090215025A1

    公开(公告)日：2009-08-27

    申请号：US12096503

    申请日：2006-12-07

    申请人： Sebastian Knor ,  Horst Kessler ,  Charlotte Hauser ,  Alexey Khrenov ,  Evgueni Saenko

    发明人： Sebastian Knor ,  Horst Kessler ,  Charlotte Hauser ,  Alexey Khrenov ,  Evgueni Saenko

    IPC分类号： C12Q1/00 ,  C07K5/117 ,  C07K7/06 ,  C07K5/113 ,  C07D209/20 ,  C12N9/96

    CPC分类号： C07K5/0205 ,  C07K5/0812 ,  C07K5/0821 ,  C07K5/1016 ,  C07K5/1024 ,  C07K7/02

    摘要： The present invention pertains to compounds that show a high affinity to Factor VIII and Factor VIII-like proteins, and their uses. The compounds are characterized by the general Formula B-Q-X, wherein B represents a dipeptide, tripeptide, or a peptidomimetic; Q represents a spacer and X represents an anchoring molecule; Q and X are optional. These compounds can be used for coating a solid support material. The resulting coated solid support material can be used for purifying Factor VIII by means of affinity chromatography methods. In addition, the compounds of the present invention may be used for stabilizing Factor VIII and for enhancing its activity. The present invention thus pertains also to methods for manufacturing a stabilized Factor VIII containing medicament of increased activity. The inventive compounds can furthermore be used in diagnostic kits and as research tools.

    摘要翻译： 本发明涉及对因子VIII和因子VIII样蛋白表现出高亲和力的化合物及其用途。 该化合物的特征在于通式B-Q-X，其中B代表二肽，三肽或拟肽; Q表示间隔基，X表示锚定分子; Q和X是可选的。 这些化合物可用于涂覆固体支持材料。 所得的包被的固体支持物质可用于通过亲和层析方法纯化因子VIII。 此外，本发明的化合物可用于稳定因子VIII并提高其活性。 因此，本发明也涉及制备具有增加的活性的含有稳定因子VIII的药物的方法。 本发明化合物还可用于诊断试剂盒和研究工具。

    MINIMIZED SMALL PEPTIDES WITH HIGH AFFINITY FOR FACTOR VIII AND FACTOR VIII-LIKE PROTEINS
    2.
    发明申请
    MINIMIZED SMALL PEPTIDES WITH HIGH AFFINITY FOR FACTOR VIII AND FACTOR VIII-LIKE PROTEINS 审中-公开
    对因子VIII和因子VIII样蛋白具有高亲和力的最小化小肽

    公开(公告)号：US20100099113A1

    公开(公告)日：2010-04-22

    申请号：US12307158

    申请日：2007-07-03

    申请人： Sebastian Knör ,  Horst Kessler ,  Charlotte Hauser ,  Evgueni Saenko ,  Alexey Khrenov

    发明人： Sebastian Knör ,  Horst Kessler ,  Charlotte Hauser ,  Evgueni Saenko ,  Alexey Khrenov

    IPC分类号： G01N33/53 ,  C07K7/06 ,  G01N33/544 ,  C07K1/14 ,  C07K14/745

    CPC分类号： C07K7/06 ,  C07K14/755

    摘要： The present invention relates to the composition of small molecules and their use in the field of protein isolation, purification, stabilizing and/or enhancing its activity. In particular, the present invention relates to the synthesis and optimization of compounds comprising small peptides and peptide derivatives with affinity to coagulation Factor VIII and/or Factor VIII-like polypeptides and/or domains thereof. These compounds are useful for labeling, detecting, identifying, isolating and preferably for purifying, stabilizing and enhancing the activity of Factor VIII, Factor VIII-like polypeptides or domains thereof from physiological and non-physiological solutions comprising same. Further, these compounds may be used as ligands, which bind Factor VIII, Factor VIII-like polypeptides or domains thereof in methods of the present invention.

    摘要翻译： 本发明涉及小分子的组成及其在蛋白质分离，纯化，稳定和/或增强其活性领域中的应用。 特别地，本发明涉及包含与凝血因子VIII和/或因子VIII样多肽和/或其结构域具有亲和力的小肽和肽衍生物的化合物的合成和优化。 这些化合物可用于从包含其的生理学和非生理学溶液中标记，检测，鉴定，分离并优选纯化，稳定和增强因子VIII，因子VIII样多肽或其结构域的活性。 此外，这些化合物可以用作本发明方法中结合因子VIII，因子VIII样多肽或其结构域的配体。