专利检索 ap:("Secretary, Department of Atomic Energy") AND inv:"Manoj K. Pal" 第 1 页

1.

发明公开
Deuterated 3,3'-Diselenodipropionic Acid (DSePA) and Its Use as an Anticancer or Radioprotective Agent 审中-公开

公开(公告)号：US20240208901A1

公开(公告)日：2024-06-27

申请号：US18087427

申请日：2022-12-22

申请人： Secretary, Department of Atomic Energy

发明人： Amit Kunwar , Manoj K. Pal , Vishwa Vipulkumar Gandhi , Sandip Dey , Ram Pada Das , Beena Gobind Singh , Amey P. Wadawale

IPC分类号： C07C391/00

CPC分类号： C07C391/00 , C07B2200/05

摘要： The present invention applies to a deuterated derivative of 3,3′-diselenodipropionic acid (D-DSePA), an organo-selenium compound and method of synthesis thereof. The invention also provides the method including D-DSePA for the inhibition of the proliferation of human non-small cell lung carcinoma (NSCLC) cells. This compound inhibits the proliferation of A549, H1975 and H3122 cells of NSCLC origin at a much lower concentration than that needed to inhibit the growth of non-cancerous lung fibroblast cells (WI-38 and WI-26 VA4). Further, D-DSePA exhibits additive effect in A549 lung cancer cells while protecting non-cancerous WI38 cells from radiotoxicity.