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公开(公告)号:US07163933B2
公开(公告)日:2007-01-16
申请号:US10369752
申请日:2003-02-21
申请人: Seiichi Ishizuka , Kazuya Takenouchi , Atsushi Imaizumi , Yasuhiro Oue , Noriyoshi Kurihara , Sakamuri V. Reddy , G. David Roodman
发明人: Seiichi Ishizuka , Kazuya Takenouchi , Atsushi Imaizumi , Yasuhiro Oue , Noriyoshi Kurihara , Sakamuri V. Reddy , G. David Roodman
IPC分类号: A61K31/59
CPC分类号: A61K31/593 , A61K31/592 , A61K38/06
摘要: To obtain a treating agent for Paget's disease of bone, there is provided a method of inhibiting expression of general transcription factor of steroid hormone receptor.
摘要翻译: 为了获得佩格特氏病的治疗剂,提供了抑制类固醇激素受体的一般转录因子表达的方法。
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公开(公告)号:US5985832A
公开(公告)日:1999-11-16
申请号:US139424
申请日:1998-08-25
CPC分类号: C12N9/6472 , C07K14/4703 , A61K38/00 , A61K39/00 , C07K2319/02
摘要: It has been found that two proteins produced by human osteoclasts inhibit osteoclast formation in bone marrow cultures and inhibit bone resorption in a fetal long bone assay. One of the proteins is identical to an Ly6 gene family protein and homologous to the Sca2 antigen, Ly6A. The second, OIP-2, is a novel protein not previously identified. The discovery of the osteoclast inhibition property of the OIP proteins suggests the therapeutic potential for patients with disordered osteoclast activity in such conditions as osteoporosis.
摘要翻译: 已经发现,人类破骨细胞产生的两种蛋白质在骨髓培养物中抑制破骨细胞形成,并在胎儿长骨测定中抑制骨吸收。 其中一种蛋白质与Ly6基因家族蛋白质相同,与Sca2抗原Ly6A同源。 第二个,OIP-2是一种未经鉴定的新蛋白。 发现OIP蛋白质的破骨细胞抑制性质表明在诸如骨质疏松症的病症中具有无序破骨细胞活性的患者的治疗潜力。
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