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![3-SUBSTITUTED-1H-INDOLE, 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES](/abs-image/US/2010/03/11/US20100061982A1/abs.jpg.150x150.jpg)
1.发明申请3-SUBSTITUTED-1H-INDOLE, 3-SUBSTITUTED-1H-PYRROLO[2,3-B]PYRIDINE AND 3-SUBSTITUTED-1H-PYRROLO[3,2-B]PYRIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES 审中-公开3-取代的1H-吲哚，3-取代的1H-吡咯并[2,3-b]吡啶和3-取代的1H-吡咯[3,2-B]吡啶化合物，它们作为MTOR激酶和PI3激酶抑制剂 ，和他们的合成公开(公告)号：US20100061982A1
公开(公告)日：2010-03-11
申请号：US12556833
申请日：2009-09-10
申请人： Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Hwei-Ru Tsou , Nan Zhang , Aranapakam Mudumbai Venkatesan , Li Di , Edward Harvel Kerns
发明人： Semiramis Ayral-Kaloustian , Tarek Suhayl Mansour , Hwei-Ru Tsou , Nan Zhang , Aranapakam Mudumbai Venkatesan , Li Di , Edward Harvel Kerns
IPC分类号： A61K39/395 , C07D405/06 , A61K31/40 , C07D403/06 , A61K31/497 , C07D498/02 , A61K31/5386
CPC分类号： C07D407/06 , C07D471/04
摘要： The invention relates to 3-substituted-1H-indole, 3-substituted-1H-pyrrolo[2,3-b]pyridine, and 3-substituted-1H-pyrrolo[3,2-b]pyridine compounds of the Formula 1: or a pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
摘要翻译： 本发明涉及式1的3-取代-1H-吲哚，3-取代-1H-吡咯并[2,3-b]吡啶和3-取代-1H-吡咯并[3,2-b]吡啶化合物： 或其药学上可接受的盐，其中组成变量如本文所定义，包含该化合物的组合物，以及制备和使用该化合物的方法。
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公开(公告)号：US07060428B2
公开(公告)日：2006-06-13
申请号：US10383335
申请日：2003-03-07
申请人： Li Di , Edward Harvel Kerns
发明人： Li Di , Edward Harvel Kerns
IPC分类号： C12Q1/00
CPC分类号： G01N33/92
摘要： The present invention provides a method for the in vitro determination of the ability of a compound or a mixture of compounds to permeate the blood-brain barrier and a membrane composition useful therefor.
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