公开(公告)号：US20090093423A2

公开(公告)日：2009-04-09

申请号：US11822956

申请日：2007-07-11

申请人： Senthilkumar UDAYAMPALAYAMPALANISAMY ,  Andrew GNANAPRAKASAM ,  Panchapakesan GANAPATHY ,  Mukut GOHAIN ,  Venkatasubramanian HARIHARAN ,  Sriram RAJAGOPAL ,  Maneesh PAUL-SATYASEELA ,  Shakti SINGH SOLANKI ,  Sathishkumar DEVARAJAN

发明人： Senthilkumar UDAYAMPALAYAMPALANISAMY ,  Andrew GNANAPRAKASAM ,  Panchapakesan GANAPATHY ,  Mukut GOHAIN ,  Venkatasubramanian HARIHARAN ,  Sriram RAJAGOPAL ,  Maneesh PAUL-SATYASEELA ,  Shakti SINGH SOLANKI ,  Sathishkumar DEVARAJAN

IPC分类号： A61K31/431 ,  A61K31/7036 ,  A61P31/00 ,  C07D499/00

CPC分类号： C07D499/86 ,  Y02P20/55

摘要： Novel 2-substituted methyl penam derivatives include the formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their solvates, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them; wherein A=C or N; Het is a three- to seven-membered heterocyclic ring; R1 represents carboxylate anion, or —COOR4 where R4 represents hydrogen, carboxylic acid protecting group or a pharmaceutically acceptable salt; R2 and R3 may be same or different and independently represent hydrogen, halogen, amino, alkyl, protected amino, optionally substituted alkyl, alkenyl, alkynyl and the like; R represents substituted or unsubstituted alkyl, alkenyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heterocyclylalkyl.

摘要翻译： 新的2-取代的甲基penam衍生物包括式（I），它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，它们的溶剂合物，其药学上可接受的盐和含有它们的药物组合物; 其中A = C或N; Het是一个三至七元的杂环; R1表示羧酸根阴离子，或-COOR4，其中R4表示氢，羧酸保护基或药学上可接受的盐; R2和R3可以相同或不同，并且独立地表示氢，卤素，氨基，烷基，保护的氨基，任选取代的烷基，烯基，炔基等; R代表取代或未取代的烷基，烯基，芳基，芳烷基，环烷基，杂环基或杂环基烷基。