公开(公告)号：US20020061894A1

公开(公告)日：2002-05-23

申请号：US09996822

申请日：2001-11-30

申请人： Sepracor Inc.

发明人： James W. Young ,  A.K. Gunnar Aberg

IPC分类号： A61K031/496

CPC分类号： A61K31/47 ,  A61K31/496 ,  Y02A50/475 ,  Y02A50/481

摘要： Methods and compositions are disclosed utilizing the optically pure (S)-isomer of lomefloxacin to treat bacterial infection. In particular, this compound is a potent drug for the treatment of Mycobacteria infection.

摘要翻译： 公开了使用洛美沙星的光学纯（S） - 异构体来治疗细菌感染的方法和组合物。 特别地，该化合物是用于治疗分枝杆菌感染的有效药物。

公开(公告)号：US20040229921A1

公开(公告)日：2004-11-18

申请号：US10872491

申请日：2004-06-22

申请人： Sepracor Inc.

发明人： James W. Young

IPC分类号： A61K031/455

CPC分类号： A61K31/44 ,  Y10S514/866 ,  Y10S514/929

摘要： Methods and compositions are disclosed utilizing the optically pure (null) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the racemic mixture of amlodipine. The (null) isomer of amlodipine is also useful for the treatment of angina and such other conditions as may be related to the activity of (null) amlodipine as a calcium channel antagonist such as cerebral ischemia, cerebral disorders, arrhythmias, cardiac hypertrophy, coronary vasospasm, myocardial infarction, renal impairment and acute renal failure, without the concomitant liability of adverse effects associated with the racemic mixture of amlodipine.

摘要翻译： 公开利用氨氯地平的光学纯（ - ）异构体的方法和组合物。 该化合物是治疗高血压的有效药物，同时避免与氨氯地平外消旋混合物相关的副作用的伴随责任。 氨氯地平的（ - ）异构体也可用于治疗心绞痛和其他可能与（ - ）氨氯地平作为钙通道拮抗剂如脑缺血，脑障碍，心律失常，心脏肥大，冠状动脉 血管痉挛，心肌梗塞，肾功能衰竭和急性肾功能衰竭，无与氨氯地平外消旋混合物相关的副作用的伴随责任。

公开(公告)号：US20030078303A1

公开(公告)日：2003-04-24

申请号：US10295871

申请日：2002-11-18

申请人： Sepracor, Inc.

发明人： James W. Young ,  Thomas P. Jerussi

IPC分类号： A61K031/137 ,  A61K031/728

CPC分类号： A61K45/06 ,  A61K31/135 ,  A61K2300/00 ,  A61K31/00

摘要： This invention encompasses methods for the treatment and prevention of disorders that include, but are not limited to, eating disorders; weight gain; obesity; irritable bowel syndrome; obsessive-compulsive disorders; platelet adhesion; apnea; affective disorders such as attention deficit disorders, depression, and anxiety; male and female sexual function disorders; restless leg syndrome; osteoarthritis; substance abuse including nicotine and cocaine addiction; narcolepsy; pain such as neuropathic pain, diabetic neuropathy, and chronic pain; migraines; cerebral function disorders; chronic disorders such as premenstrual syndrome; and incontinence. The invention further encompasses pharmaceutical compositions and dosage forms which comprise optically pure (null) sibutramine, optionally in combination with a phosphodiesterase inhibitor or a lipase inhibitor.

摘要翻译： 本发明包括治疗和预防包括但不限于进食障碍的疾病的方法; 体重增加; 肥胖; 过敏性肠综合征; 强迫症; 血小板粘附; 呼吸暂停 情感障碍，如注意力缺陷障碍，抑郁症和焦虑症; 男性和女性性功能障碍; 不安腿综合征 骨关节炎 药物滥用，包括尼古丁和可卡因成瘾; 发作性睡病 疼痛如神经性疼痛，糖尿病性神经病和慢性疼痛; 偏头痛 脑功能障碍; 慢性疾病如经前期综合征; 和失禁。 本发明还包括药物组合物和剂型，其包含光学纯的（+）西布曲明，任选与磷酸二酯酶抑制剂或脂肪酶抑制剂组合。

公开(公告)号：US20030050328A1

公开(公告)日：2003-03-13

申请号：US10206878

申请日：2002-07-29

申请人： Sepracor Inc.

发明人： James W. Young

IPC分类号： A61K031/44

CPC分类号： A61K31/44 ,  Y10S514/866 ,  Y10S514/929

摘要： Methods and compositions are disclosed utilizing the optically pure (null) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the racemic mixture of amlodipine. The (null) isomer of amlodipine is also useful for the treatment of angina and such other conditions as may be related to the activity of (null) amlodipine as a calcium channel antagonist such as cerebral ischemia, cerebral disorders, arrhythmias, cardiac hypertrophy, coronary vasospasm, myocardial infarction, renal impairment and acute renal failure, without the concomitant liability of adverse effects associated with the racemic mixture of amlodipine.

摘要翻译： 公开利用氨氯地平的光学纯（ - ）异构体的方法和组合物。 该化合物是治疗高血压的有效药物，同时避免与氨氯地平外消旋混合物相关的副作用的伴随责任。 氨氯地平的（ - ）异构体也可用于治疗心绞痛和其他可能与（ - ）氨氯地平作为钙通道拮抗剂如脑缺血，脑障碍，心律失常，心脏肥大，冠状动脉 血管痉挛，心肌梗塞，肾功能衰竭和急性肾功能衰竭，无与氨氯地平外消旋混合物相关的副作用的伴随责任。

公开(公告)号：US20020115726A1

公开(公告)日：2002-08-22

申请号：US10076645

申请日：2002-02-19

申请人： Sepracor, Inc.

发明人： James W. Young

IPC分类号： A61K031/137

CPC分类号： A61K31/137 ,  A61K31/135

摘要： Methods and compositions are disclosed utilizing the optically pure (null)-isomer of bupropion, which is a potent drug for treating depression, Parkinson's disease, obesity, weight gain and other disorders.

摘要翻译： 公开利用安非他酮的光学纯（ - ） - 异构体的方法和组合物，其是用于治疗抑郁症，帕金森病，肥胖，体重增加和其它障碍的有效药物。

公开(公告)号：US20020010200A1

公开(公告)日：2002-01-24

申请号：US09915573

申请日：2001-07-27

申请人： Sepracor Inc.

发明人： James W. Young

IPC分类号： A61K031/44

CPC分类号： A61K31/44 ,  Y10S514/866 ,  Y10S514/929

摘要： Methods and compositions are disclosed utilizing the optically pure (null) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the racemic mixture of amlodipine. The (null) isomer of amlodipine is also useful for the treatment of angina and such other conditions as may be related to the activity of (null) amlodipine as a calcium channel antagonist such as cerebral ischemia, cerebral disorders, arrhythmias, cardiac hypertrophy, coronary vasospasm, myocardial infarction, renal impairment and acute renal failure, without the concomitant liability of adverse effects associated with the racemic mixture of amlodipine.

摘要翻译： 公开利用氨氯地平的光学纯（ - ）异构体的方法和组合物。 该化合物是治疗高血压的有效药物，同时避免与氨氯地平外消旋混合物相关的副作用的伴随责任。 氨氯地平的（ - ）异构体也可用于治疗心绞痛和其他可能与（ - ）氨氯地平作为钙通道拮抗剂如脑缺血，脑障碍，心律失常，心脏肥大，冠状动脉 血管痉挛，心肌梗塞，肾功能衰竭和急性肾功能衰竭，无与氨氯地平外消旋混合物相关的副作用的伴随责任。

公开(公告)号：US20030022942A1

公开(公告)日：2003-01-30

申请号：US10202830

申请日：2002-07-26

申请人： Sepracor, Inc.

发明人： James W. Young

IPC分类号： A61K031/137

CPC分类号： A61K31/137 ,  A61K31/135

摘要： Methods and compositions are disclosed utilizing the optically pure (null)-isomer of bupropion, which is a potent drug for treating depression, Parkinson's disease, obesity, weight gain and other disorders.

公开(公告)号：US20020006965A1

公开(公告)日：2002-01-17

申请号：US09891266

申请日：2001-06-27

申请人： Sepracor Inc.

发明人： James W. Young

IPC分类号： A61K031/135

CPC分类号： A61K31/137 ,  A61K31/135

摘要： Methods and compositions are disclosed utilizing the optically pure (null)-isomer of bupropion, which is a potent drug for treating depression, Parkinson's disease, obesity, weight gain and other disorders.

摘要翻译： 公开利用安非他酮的光学纯（ - ） - 异构体的方法和组合物，其是用于治疗抑郁症，帕金森病，肥胖，体重增加和其它障碍的有效药物。

公开(公告)号：US20010029260A1

公开(公告)日：2001-10-11

申请号：US09840117

申请日：2001-04-24

申请人： Sepracor Inc.

发明人： James W. Young

IPC分类号： A61K031/44

CPC分类号： A61K31/44 ,  Y10S514/866 ,  Y10S514/929

摘要： Methods and compositions are disclosed utilizing the optically pure (null) isomer of amlodipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the racemic mixture of amlodipine. The (null) isomer of amlodipine is also useful for the treatment of angina and such other conditions as may be related to the activity of (null) amlodipine as a calcium channel antagonist such as cerebral ischemia, cerebral disorders, arrhythmias, cardiac hypertrophy, coronary vasospasm, myocardial infarction, renal impairment and acute renal failure, without the concomitant liability of adverse effects associated with the racemic mixture of amlodipine.

摘要翻译： 公开利用氨氯地平的光学纯（ - ）异构体的方法和组合物。 该化合物是治疗高血压的有效药物，同时避免与氨氯地平外消旋混合物相关的副作用的伴随责任。 氨氯地平的（ - ）异构体也可用于治疗心绞痛和其他可能与（ - ）氨氯地平作为钙通道拮抗剂如脑缺血，脑障碍，心律失常，心脏肥大，冠状动脉 血管痉挛，心肌梗塞，肾功能衰竭和急性肾功能衰竭，无与氨氯地平外消旋混合物相关的副作用的伴随责任。

公开(公告)号：US20010012842A1

公开(公告)日：2001-08-09

申请号：US09794006

申请日：2001-02-28

申请人： Sepracor Inc.

发明人： James W. Young ,  A.K. Gunnar Aberg

IPC分类号： A61K031/496

CPC分类号： A61K31/47 ,  A61K31/496 ,  Y02A50/475 ,  Y02A50/481

摘要： Methods and compositions are disclosed utilizing the optically pure (S)-isomer of lomefloxacin to treat bacterial infection. In particular, this compound is a potent drug for the treatment of Mycobacteria infection.

摘要翻译： 公开了使用洛美沙星的光学纯（S） - 异构体来治疗细菌感染的方法和组合物。 特别地，该化合物是用于治疗分枝杆菌感染的有效药物。