公开(公告)号：US08350077B2

公开(公告)日：2013-01-08

申请号：US12734183

申请日：2008-12-24

申请人： Sergej Vladimirovich Burov ,  Natalia Vasilyevna Khromova ,  Anna Alexandrovna Khromova ,  Petr Alekseevich Khromov

发明人： Sergej Vladimirovich Burov ,  Natalia Vasilyevna Khromova ,  Anna Alexandrovna Khromova ,  Petr Alekseevich Khromov

IPC分类号： C07C229/26 ,  C07C231/00 ,  C07C237/20

CPC分类号： A61K31/16 ,  C07C279/14

摘要： The invention relates to pharmaceutical chemistry notably to new biologically active substances (BAS) and their properties. In particular, the invention relates to Creatine derivatives having a general formula: NH═C(NH2)—N(CH3)—CH2—CO—NH—R*X, wherein R—amino acid residue of aliphatic, aromatic or heteroaromatic L-amino acid or its derivative representing a salts of amino acid, amino acid esters, amino acid amides or peptides; X—lower organic or mineral acid or water. New substances are prepared by interaction of aforesaid amides of sarcosine having a general formula of HN(CH3)—CH2—CO—NH—R*X, wherein: R is amino acid residue or substituted amino acid residue; X is low-molecular-weight organic acid or mineral acid or water, with a guanidinylating agents with the in organic solvents at temperature not exceeding 50° C. New chemical compounds can be used as a remedy possessing a neuroprotective activity.

摘要翻译： 本发明涉及药物化学，特别涉及新的生物活性物质（BAS）及其性质。 特别地，本发明涉及具有以下通式的肌酸衍生物：NH = C（NH 2）-N（CH 3）-CH 2 -CO-NH-R * X，其中脂族，芳族或杂芳族L- 代表氨基酸，氨基酸酯，氨基酸酰胺或肽的氨基酸或其衍生物; X-有机或无机酸或水。 新物质通过上述具有通式HN（CH 3）-CH 2 -CO-NH-R * X的肌氨酸酰胺的相互作用制备，其中：R是氨基酸残基或取代的氨基酸残基; X是低分子量有机酸或无机酸或水，在有机溶剂中的胍基化剂温度不超过50℃。新化合物可用作具有神经保护活性的补救剂。

公开(公告)号：US20110269986A1

公开(公告)日：2011-11-03

申请号：US12734183

申请日：2008-12-24

申请人： Sergej Vladimirovich Burov ,  Natalia Vasilyevna Khromova ,  Anna Alexandrovna Khromova ,  Petr Alekseevich Khromov

发明人： Sergej Vladimirovich Burov ,  Natalia Vasilyevna Khromova ,  Anna Alexandrovna Khromova ,  Petr Alekseevich Khromov

IPC分类号： C07C229/26 ,  C07C237/20 ,  C07C231/00 ,  C07C227/14

CPC分类号： A61K31/16 ,  C07C279/14

摘要： The invention relates to pharmaceutical chemistry notably to new biologically active substances (BAS) and their properties. In particular, the invention relates to Creatine derivatives having a general formula: NH═C(NH2)—N(CH3)—CH2—CO—NH—R*X, wherein R—amino acid residue of aliphatic, aromatic or heteroaromatic L-amino acid or its derivative representing a salts of amino acid, amino acid esters, amino acid amides or peptides; X—lower organic or mineral acid or water. New substances are prepared by interaction of aforesaid amides of sarcosine having a general formula of HN(CH3)—CH2—CO—NH—R*X, wherein: R is amino acid residue or substituted amino acid residue; X is low-molecular-weight organic acid or mineral acid or water, with a guanidinylating agents with the in organic solvents at temperature not exceeding 50° C. New chemical compounds can be used as a remedy possessing a neuroprotective activity.

摘要翻译： 本发明涉及药物化学，特别涉及新的生物活性物质（BAS）及其性质。 特别地，本发明涉及具有以下通式的肌酸衍生物：NH = C（NH 2）-N（CH 3）-CH 2 -CO-NH-R * X，其中脂族，芳族或杂芳族L- 代表氨基酸，氨基酸酯，氨基酸酰胺或肽的氨基酸或其衍生物; X-有机或无机酸或水。 新物质通过上述具有通式HN（CH 3）-CH 2 -CO-NH-R * X的肌氨酸酰胺的相互作用制备，其中：R是氨基酸残基或取代的氨基酸残基; X是低分子量有机酸或无机酸或水，在有机溶剂中的胍基化剂温度不超过50℃。新化合物可用作具有神经保护活性的补救剂。