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1.发明申请MONITORING OF IMMUNE SYSTEM USING PERIPHERAL BLOOD MICRO-RNA EXPRESSION PROFILE ANALYSIS AND USES THEREOF 审中-公开使用外周血微量RNA表达谱分析及其用途监测免疫系统公开(公告)号：US20130165497A1
公开(公告)日：2013-06-27
申请号：US13703730
申请日：2011-06-15
IPC分类号： C12Q1/68 , A61K31/7105
CPC分类号： C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to a method for monitoring the immune system of an individual, which comprises measuring, preferably by quantitative RT-PCR, the expression level of at least one microRNA (miRNA) gene product in a peripheral blood sample or in a biological fluid sample, and comparing said measured expression level with a reference level. In particular, the at least one miRNA gene product, which the method of the invention measures, is expressed by lymphocyte populations of an individual, in particular by naive CD4+T, TH1, TH2 and TH17 lymphocytes. The method of the invention is useful for the diagnosis, prognosis, prevention, control and/or the treatment of a pathological condition caused by or associated with an immune system dysfunction. Moreover, the method of the present invention is useful for monitoring, in an individual, the evolution of conditions mediated by the immune system, such as the response to a vaccination.
摘要翻译： 本发明涉及一种用于监测个体的免疫系统的方法，其包括优选通过定量RT-PCR测量外周血样品或生物液体中至少一种微小RNA（miRNA）基因产物的表达水平 采样，并将所述测量的表达水平与参考水平进行比较。 特别地，本发明的方法测量的至少一种miRNA基因产物由个体的淋巴细胞群体特别是天然的CD4 + T，TH1，TH2和TH17淋巴细胞表达。 本发明的方法可用于诊断，预后，预防，控制和/或治疗由免疫系统功能障碍引起或与免疫系统功能障碍相关的病理状况。 此外，本发明的方法可用于在个体中监测由免疫系统介导的病症的进化，例如对疫苗接种的反应。
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