公开(公告)号：US20230149524A1

公开(公告)日：2023-05-18

申请号：US17753248

申请日：2020-09-02

申请人： Serum Institute of India Private Limited

发明人： Rajeev Mhalasakant Dhere ,  Sambhaji Shankar Pisal ,  Dattatreya Sarma Annamraju ,  Nikhil Dattatray Avalaskar ,  Yogesh Tukaram Hundekari ,  Anil Pirajirao Taklikar ,  Sunil Kumar Goel ,  Chandrashekhar Dwarkanath Kamat ,  Vishal Bharat Chavan

IPC分类号： A61K39/112 ,  A61K47/64 ,  A61P31/04

CPC分类号： A61K39/0275 ,  A61K47/646 ,  A61K47/6415 ,  A61P31/04 ,  A61K2039/6037

摘要： The present disclosure relates to novel immunogenic monovalent and multivalent polysaccharide-protein conjugate vaccine compositions comprising a polysaccharide selected from Salmonella serovar strains S. typhi; S. paratyphi A; S. typhimurium and S. enteritidis and alternative improved methods of polysaccharide fermentation, polysaccharide purification, polysaccharide-protein conjugation and stable formulation. The present disclosure further relates to methods for inducing an immune response in subjects against Salmonella typhi and non-typhi related diseases and/or for reducing or preventing Salmonella typhi and non-typhi related diseases in subjects using the compositions disclosed herein. The vaccine elicits bactericidal antibodies and is useful for prevention of gastroenteritis, enteric and typhoid fever.