公开(公告)号：US20070265329A1

公开(公告)日：2007-11-15

申请号：US11433917

申请日：2006-05-12

申请人： Shah Devang ,  John Barr ,  Brian Baxter ,  Jorge Heller

发明人： Shah Devang ,  John Barr ,  Brian Baxter ,  Jorge Heller

IPC分类号： A61K31/405

CPC分类号： A61K9/0019 ,  A61K9/08 ,  A61K31/405 ,  A61K47/14 ,  A61K47/34

摘要： A pharmaceutical composition for the sustained release of an effective amount of a selective 5-hydroxytryptamine 3 (5-HT3) receptor antagonist for the prevention, reduction or alleviation of acute and delayed chemotherapy-induced nausea and vomiting (CINV) following a course of emetogenic chemotherapy, wherein the composition is administered by subcutaneous injection, the composition comprising a 5-HT3 receptor antagonist, a semi-solid delivery vehicle and a pharmaceutically acceptable liquid excipient; wherein the composition, when administered in a single dosage, provides a controlled release of the 5-HT3 receptor antagonist and prolonging the release of the 5-HT3 receptor antagonist that tracks the profile of the incidence of vomiting.

摘要翻译： 用于持续释放有效量的选择性5-羟色胺3（5-HT 3 N）受体拮抗剂用于预防，减少或缓解急性和延迟化疗引起的恶心和呕吐的药物组合物 （CINV），其中所述组合物通过皮下注射施用，所述组合物包含5-HT 3受体拮抗剂，半固体递送载体和药学上可接受的液体赋形剂; 其中当以单一剂量施用时，所述组合物提供5-HT 3受体拮抗剂的受控释放并延长5-HT 3受体拮抗剂的释放，所述5-HT 3受体拮抗剂的释放 跟踪呕吐发生的概况。