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公开(公告)号：US11840518B2
公开(公告)日：2023-12-12
申请号：US17869819
申请日：2022-07-21
发明人： Dayong Shi , Xiangqian Li , Xin Wang , Feng Xu
IPC分类号： C07D231/06 , A61P31/14
CPC分类号： C07D231/06 , A61P31/14
摘要： The present invention belongs to the field of medical technology, and specifically relates to use of bromophenol-pyrazoline compounds for the treatment of feline coronavirus diseases. Studies carried out for the present invention revealed that bromophenol-pyrazoline compounds could inhibit activity of feline infectious peritonitis virus main protease (FIPV Mpro) and interfere with replication of feline infectious peritonitis virus (FIPV) in cells. In a clinical trial, the bromophenol-pyrazoline compounds can treat infectious peritonitis in cats naturally infected with the FIPV, greatly improve survival rate of cats, and can be used to prepare drugs for treating feline infectious peritonitis.
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公开(公告)号：US20220193036A1
公开(公告)日：2022-06-23
申请号：US17478134
申请日：2021-09-17
发明人： Dayong Shi , Xiangqian Li , Xin Wang , Jinbo Yang , Feng Xu , Rong Zhang
IPC分类号： A61K31/415 , A61K31/428 , A61P31/14
摘要： The invention belongs to the technical field of medicine, and particularly relates to use of bromophenol-pyrazoline compounds in the treatment of porcine coronavirus diseases. Through the research in the invention, it is found that the bromophenol-pyrazoline compounds inhibit replication of porcine coronaviruses at a cellular level, and can treat porcine coronavirus diseases (such as PEDV and TGEV) in clinical trials, greatly improving the survival rate of infected piglets, so the compounds can be used to prepare drugs for treating porcine coronavirus diseases.
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公开(公告)号：US11752133B2
公开(公告)日：2023-09-12
申请号：US17478134
申请日：2021-09-17
发明人： Dayong Shi , Xiangqian Li , Xin Wang , Jinbo Yang , Feng Xu , Rong Zhang
IPC分类号： A61K31/415 , A61P31/14 , A61K31/428 , A61K31/427
CPC分类号： A61K31/415 , A61K31/427 , A61K31/428 , A61P31/14
摘要： The invention belongs to the technical field of medicine, and particularly relates to use of bromophenol-pyrazoline compounds in the treatment of porcine coronavirus diseases. Through the research in the invention, it is found that the bromophenol-pyrazoline compounds inhibit replication of porcine coronaviruses at a cellular level, and can treat porcine coronavirus diseases (such as PEDV and TGEV) in clinical trials, greatly improving the survival rate of infected piglets, so the compounds can be used to prepare drugs for treating porcine coronavirus diseases.
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公开(公告)号：US20220363644A1
公开(公告)日：2022-11-17
申请号：US17869819
申请日：2022-07-21
发明人： Dayong Shi , Xiangqian Li , Xin Wang , Feng Xu
IPC分类号： C07D231/06 , A61P31/14
摘要： The present invention belongs to the field of medical technology, and specifically relates to use of bromophenol-pyrazoline compounds for the treatment of feline coronavirus diseases. Studies carried out for the present invention revealed that bromophenol-pyrazoline compounds could inhibit activity of feline infectious peritonitis virus main protease (FIPV Mpro) and interfere with replication of feline infectious peritonitis virus (FIPV) in cells. In a clinical trial, the bromophenol-pyrazoline compounds can treat infectious peritonitis in cats naturally infected with the FIPV, greatly improve survival rate of cats, and can be used to prepare drugs for treating feline infectious peritonitis.
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