公开(公告)号：US11110094B2

公开(公告)日：2021-09-07

申请号：US16525502

申请日：2019-07-29

申请人： Shandong Luye Pharmaceutical Co., Ltd. ,  Nanjing Luye Pharmaceutical Co., Ltd.

发明人： Kaoxiang Sun ,  Rongcai Liang ,  Oilin Wang ,  Wenyan Wang ,  Wanhui Liu ,  Youxin Li

IPC分类号： A61K9/50 ,  A61K31/519 ,  A61K9/19 ,  A61K9/16 ,  A61K9/14 ,  A61K47/34 ,  A61K9/00 ,  A61K9/48

摘要： A risperidone sustained release microsphere formulation is provided. The microsphere formulation comprise risperidone or 9-hydroxy risperidone or salts thereof, and a polymer blend having a first uncapped lactide-glycolide copolymer and a second uncapped lactide-glycolide copolymer, in which the first uncapped lactide-glycolide copolymer is a copolymer with a high intrinsic viscosity and the second uncapped lactide-glycolide copolymer is a copolymer with a low intrinsic viscosity. The sustained release microsphere formulation according to an embodiment of the present disclosure is suitable for large-scale industrialized production with improved stability, the in vivo release behavior of which will not change after long-term storage.