公开(公告)号：US20210261539A1

公开(公告)日：2021-08-26

申请号：US16967664

申请日：2019-02-01

申请人： Shanghai Haihe Pharmaceutical Co., Ltd. ,  Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： Lin Xia ,  Meiyu Geng ,  Yan Ye ,  Jian Ding ,  Qiong Zhang ,  Aijun Shen ,  Ying Huang ,  Hongchun Liu ,  Haoran Yang ,  Jing Ai ,  Minmin Zhang

IPC分类号： C07D471/04 ,  C07D519/00 ,  C07D403/04 ,  C07D498/04 ,  C07D401/14 ,  C07D487/04 ,  C07D413/14

摘要： The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical composition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.