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公开(公告)号：US20230134869A1
公开(公告)日：2023-05-04
申请号：US17914671
申请日：2021-04-02
发明人： Xiaolan Zhan , Linsong Guo
IPC分类号： C07D401/14 , C07D513/10 , C07D498/10 , C07D471/10 , A61P35/00
摘要： The present invention relates to a crystal form of the free alkali of nitrogen-containing aromatic derivatives. In particular, the present invention relates to a crystal form of the compound represented by the general formula (I), its preparation method and a pharmaceutical composition containing a therapeutically effective amount of the crystal form, and the use thereof as a protein tyrosine phosphatase-2C (SHP2) inhibitor in the treatment of diseases or conditions such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colorectal cancer.
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2.发明申请公开(公告)号：US20230014383A1
公开(公告)日：2023-01-19
申请号：US17777966
申请日：2020-11-19
发明人： Xiaolan Zhan , Linsong Guo
IPC分类号： C07D498/04 , C07D498/14
摘要： A three fused ring derivative-containing salt and a crystal form thereof. In particular, the present invention relates to a compound having general formula (I), a crystal form thereof, a preparation method therefor, a pharmaceutical composition containing a therapeutically effective amount of the compound and the crystal form thereof, and use thereof in the preparation of a medicament for treating PI3K-mediated related diseases.
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