公开(公告)号：US20220213083A1

公开(公告)日：2022-07-07

申请号：US17603823

申请日：2020-04-20

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： Huaqiang XU ,  Jia LI ,  Jingjing SHI ,  Yi ZANG ,  Dandan SUN ,  Mingliang LIU ,  Rongrong XIE ,  Erli YOU ,  Lixin GAO ,  Qian TAN

IPC分类号： C07D413/14 ,  C07D487/08 ,  A61P1/16

摘要： An FXR small molecule agonist and a preparation method therefor and a use thereof, having a structure as shown in formula (I). The compound represented by formula (I) has FXR agonistic activity and is capable of preparing drugs for treatment of FXR-related diseases.

公开(公告)号：US20230357244A1

公开(公告)日：2023-11-09

申请号：US18029359

申请日：2021-09-28

申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences

发明人： Huaqiang XU ,  Jia LI ,  Jingjing SHI ,  Yi ZANG ,  Dandan SUN ,  Mingliang LIU ,  Rongrong XIE ,  Erli YOU ,  Lixin GAO ,  Qian TAN

IPC分类号： C07D471/08

CPC分类号： C07D471/08

摘要： A strong FXR small-molecule agonist, and a preparation method therefor and use thereof, the structure of the agonist being represented by formula (I), are provided. In the formula, each substituent is as defined in the description and the claims. The compound provided has the advantages of high FXR agonist activity, simple synthesis, easily available raw materials and the like, and can be used for preparing medicines for treating FXR related diseases.