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公开(公告)号：US20220098178A1
公开(公告)日：2022-03-31
申请号：US17442899
申请日：2020-03-24
发明人： Xin XU , Jia CHEN , Zhen ZHANG , Liming ZHANG , Qimei WU , Qingyun JIANG , Fengying GUO , Yuyun ZHANG , Hao YU , Ying WANG , Kang SUN , Chengxu ZANG , Chenggang QIN , Xiaobo ZHOU , Xiaojuan ZHANG , Yijin WANG , Xiaoer XIA , Yunfei LI , Jian GE
IPC分类号： C07D405/14 , A61P35/00 , C07D405/12 , C07D487/04
摘要： The present invention relates to a preparation method for an amide compound and an application thereof in the field of medicine. Specifically, provided by the present invention is an amide small molecule compound which is an inhibitor of Zeste gene enhancer homolog 2 (EZH2) and which may be used to prevent and/or treat EZH2-mediated related diseases, comprising tumors, myeloproliferative diseases or autoimmune diseases.
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公开(公告)号：US20220024941A1
公开(公告)日：2022-01-27
申请号：US17442331
申请日：2020-03-24
发明人： Xin XU , Jia CHEN , Zhen ZHANG , Liming ZHANG , Qimei WU , Qingyun JIANG , Fengying GUO , Yuyun ZHANG , Hao YU , Xiaojuan ZHANG , Kang SUN , Xiaobo ZHOU , Chengxu ZANG , Yijin WANG , Xiaoer XIA , Yunfei LI , Jian GE
IPC分类号： C07D491/107 , C07D471/10 , C07D405/14 , C07D495/10
摘要： Provided are a preparation method for amide compounds and use thereof in medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer homolog 2 (EZH2) of Zeste gene, and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.
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