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1.Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease 有权
标题翻译: A2B腺苷受体拮抗剂治疗炎症性肠病公开(公告)号:US20080176845A1
公开(公告)日:2008-07-24
申请号:US11982817
申请日:2007-11-05
申请人: Shanthi V. Sitaraman , Joel M. Linden , Guoquan Wang , Robert Douglas Thompson , Jayson M. Rieger
发明人: Shanthi V. Sitaraman , Joel M. Linden , Guoquan Wang , Robert Douglas Thompson , Jayson M. Rieger
IPC分类号: A61K31/52 , A61P1/00 , A61K31/519 , A61K31/5377
CPC分类号: A61K31/519 , A61K31/52 , A61K31/5377
摘要: The present invention relates to method for treating inflammatory bowel disease that includes administration of an effective amount of an antagonist of A2B adenosine receptors (ARs).
摘要翻译: 本发明涉及治疗炎性肠病的方法,其包括施用有效量的Aβ2A腺苷受体(ARs)拮抗剂。
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2.Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease 有权
标题翻译: A2B腺苷受体拮抗剂治疗炎症性肠病公开(公告)号:US08193200B2
公开(公告)日:2012-06-05
申请号:US11982817
申请日:2007-11-05
申请人: Shanthi V. Sitaraman , Joel M. Linden , Guoquan Wang , Robert Douglas Thompson , Jayson M. Rieger
发明人: Shanthi V. Sitaraman , Joel M. Linden , Guoquan Wang , Robert Douglas Thompson , Jayson M. Rieger
IPC分类号: A61K31/522 , A61K31/496
CPC分类号: A61K31/519 , A61K31/52 , A61K31/5377
摘要: The present invention relates to method for treating inflammatory bowel disease that includes administration of an effective amount of an antagonist of A2B adenosine receptors (ARs).
摘要翻译: 本发明涉及治疗炎性肠病的方法,其包括施用有效量的A2B腺苷受体拮抗剂(AR)。
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3.2-polycyclic propynyl adenosine analogs having A2A agonist activity 失效
标题翻译: 具有A2A激动剂活性的2-多环丙炔基腺苷类似物公开(公告)号:US07442687B2
公开(公告)日:2008-10-28
申请号:US11196802
申请日:2005-08-02
申请人: Jayson M. Rieger , Joel M. Linden , Timothy L. Macdonald , Gail W. Sullivan , Lauren J. Murphree , Robert Alan Figler , Robert Douglas Thompson
发明人: Jayson M. Rieger , Joel M. Linden , Timothy L. Macdonald , Gail W. Sullivan , Lauren J. Murphree , Robert Alan Figler , Robert Douglas Thompson
CPC分类号: C07H19/16
摘要: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
摘要翻译: 本发明提供具有以下通式(I)的化合物:其中X,R 1,R 2,R 7和Z如上所述 这里。
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4.2-polycyclic propynyl adenosine analogs having A2A agonist activity 有权
标题翻译: 具有A2A激动剂活性的2-多环丙炔基腺苷类似物公开(公告)号:US07576069B2
公开(公告)日:2009-08-18
申请号:US11196798
申请日:2005-08-02
申请人: Jayson M. Rieger , Joel M. Linden , Timothy L. Macdonald , Gail W. Sullivan , Lauren J. Murphree , Robert Alan Figler , Robert Douglas Thompson
发明人: Jayson M. Rieger , Joel M. Linden , Timothy L. Macdonald , Gail W. Sullivan , Lauren J. Murphree , Robert Alan Figler , Robert Douglas Thompson
CPC分类号: A61K51/0491 , C07H19/16
摘要: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
摘要翻译: 本发明提供具有以下通式(I)的化合物:其中X,R 1,R 2,R 7和Z如本文所述。
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5.2-polycyclic propynyl adenosine analogs having A2A agonist activity 有权
标题翻译: 具有A2A激动剂活性的2-多环丙炔基腺苷类似物公开(公告)号:US07875595B2
公开(公告)日:2011-01-25
申请号:US12487265
申请日:2009-06-18
申请人: Jayson M. Rieger , Joel M. Linden , Timothy L. Macdonald , Gail W. Sullivan , Lauren J. Murphree , Robert Alan Figler , Robert Douglas Thompson
发明人: Jayson M. Rieger , Joel M. Linden , Timothy L. Macdonald , Gail W. Sullivan , Lauren J. Murphree , Robert Alan Figler , Robert Douglas Thompson
CPC分类号: A61K51/0491 , C07H19/16
摘要: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
摘要翻译: 本发明提供具有以下通式(I)的化合物:其中X,R 1,R 2,R 7和Z如本文所述。
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6.
公开(公告)号:US20090298788A1
公开(公告)日:2009-12-03
申请号:US12487265
申请日:2009-06-18
申请人: Jayson M. Rieger , Joel M. Linden , Timothy L. Macdonald , Gail W. Sullivan , Lauren J. Murphree , Robert Alan Figler , Robert Douglas Thompson
发明人: Jayson M. Rieger , Joel M. Linden , Timothy L. Macdonald , Gail W. Sullivan , Lauren J. Murphree , Robert Alan Figler , Robert Douglas Thompson
IPC分类号: A61K31/7076 , A61P29/00
CPC分类号: A61K51/0491 , C07H19/16
摘要: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
摘要翻译: 本发明提供了具有以下通式(I)的化合物:其中X,R 1,R 2,R 7和Z如本文所述。
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公开(公告)号:US20090162282A1
公开(公告)日:2009-06-25
申请号:US12338599
申请日:2008-12-18
IPC分类号: A61K51/04 , C07H19/16 , A61K31/7064 , A61P27/14 , A61P9/00 , A61P7/12 , A61P19/06 , A61P9/10
CPC分类号: C07H19/16
摘要: The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
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8.Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists 有权
标题翻译: 取代的4- {3- [6-氨基-9-(3,4-二羟基 - 四氢 - 呋喃-2-基)-9H-嘌呤-2-基] - 丙-2-炔基} - 哌啶-1-甲酸 酸酯作为A2AR激动剂公开(公告)号:US08058259B2
公开(公告)日:2011-11-15
申请号:US12338599
申请日:2008-12-18
CPC分类号: C07H19/16
摘要: The present invention provides substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
摘要翻译: 本发明提供取代的4- {3- [6-氨基-9-(3,4-二羟基 - 四氢 - 呋喃-2-基)-9H-嘌呤-2-基] - 丙-2-炔基} - 哌啶 -1-羧酸酯和含有与A2A腺苷受体(AR)的选择性激动剂相同的药物组合物。 这些化合物和组合物可用作药剂。
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