公开(公告)号：US20240108047A1

公开(公告)日：2024-04-04

申请号：US17762078

申请日：2021-05-31

申请人： Shaoxing Tongchuang Biotechnology Co., Ltd.

发明人： Mingfei YAO ,  Shengyi HAN ,  Xin JIN ,  Weixin HUANG ,  Jiaojiao XIE ,  Yanmeng LU ,  Bona WANG ,  Ling GAO ,  Chihui YU ,  Lanjuan LI

IPC分类号： A23L33/135 ,  A23L29/212 ,  A23L29/262 ,  A23L29/275 ,  A23P10/30 ,  A61K9/48 ,  A61K9/50 ,  A61K35/747

CPC分类号： A23L33/135 ,  A23L29/212 ,  A23L29/262 ,  A23L29/275 ,  A23P10/30 ,  A61K9/4808 ,  A61K9/4866 ,  A61K9/5036 ,  A61K9/5089 ,  A61K35/747 ,  A23V2400/181 ,  A61K2035/115

摘要： The invention provides a Probiotic microcapsule and a preparation method thereof, relating to the technical field of Probiotic products. The method includes the following steps: (a) preparing a capsule core containing Probiotics: mixing the capsule core materials including Probiotic powder, microcrystalline cellulose and starch, then adding a hydroxypropyl methylcellulose solution thereinto, while mixing evenly, making the obtained mixture materials into spherical particulate capsule cores by the extrusion spherization method; (b) coating by atomization: coating the microcapsule cores with a coating material solution in a single layer or multiple layers by atomization, getting core-shell microcapsules. The Probiotic microcapsules prepared by the present invention have a large encapsulation, uniform microcapsule particles, controllable particle size, storage-resistance, targetability to intestinal tracts, resistance to gastric acids and high temperature stability.